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Tocris/GW 791343 hydrochloride/3385/50/50 mg

Description:P2X7allostericmodulator
ChemicalName:2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamidetrihydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

P2X7allostericmodulator.Exhibitsspecies-specificactivity;actsasanegativeallostericmodulatorofhumanP2X7(pIC50=6.9-7.2)andapositiveallostericmodulatorofratP2X7.

TechnicalData

M.Wt483.81
FormulaC20H24F2N4O.3HCl
StorageDesiccateatRT
Purity≥99%(HPLC)
CASNumber309712-55-8
PubChemID9848159
InChIKeyWSBRAHWNJBXXJM-UHFFFAOYSA-N
SmilesCC(C=C2)=C(NC(CNC3=CC=C(F)C(F)=C3)=O)C=C2CN1CCNCC1.Cl.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO48.38100
water48.38100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight483.81.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.07mL10.33mL20.67mL
5mM0.41mL2.07mL4.13mL
10mM0.21mL1.03mL2.07mL
50mM0.04mL0.21mL0.41mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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