P2X7allostericmodulator.Exhibitsspecies-specificactivity;actsasanegativeallostericmodulatorofhumanP2X7(pIC50=6.9-7.2)andapositiveallostericmodulatorofratP2X7.
M.Wt | 483.81 |
Formula | C20H24F2N4O.3HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 309712-55-8 |
PubChemID | 9848159 |
InChIKey | WSBRAHWNJBXXJM-UHFFFAOYSA-N |
Smiles | CC(C=C2)=C(NC(CNC3=CC=C(F)C(F)=C3)=O)C=C2CN1CCNCC1.Cl.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 48.38 | 100 | |
water | 48.38 | 100 |
Thefollowingdataisbasedontheproductmolecularweight483.81.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.07mL | 10.33mL | 20.67mL |
5mM | 0.41mL | 2.07mL | 4.13mL |
10mM | 0.21mL | 1.03mL | 2.07mL |
50mM | 0.04mL | 0.21mL | 0.41mL |
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