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Tocris/SB 269970 hydrochloride/1612/50/50 mg

Description:Potentandselective5-HT7antagoNIST;brainpenetrant
ChemicalName:(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidinehydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselective5-HT7receptorantagonist(pKivaluesare8.9,7.2and6.0for5-HT7A,5-HT5Aand5-HT1Band<6.0for5-HT1A,5-HT1D,5-HT1E,5-HT1F,5-HT2A,5-HT2B,5-HT2C,5-HT4and5-HT6receptorsrespectively).Brainpenetrantinvivo.

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline.

CompoundLibraries

SB269970hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt388.95
FormulaC18H28N2O3S.HCl
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber261901-57-9
PubChemID11957684
InChIKeyXQCJOYZLWFNDIO-PKLMIRHRSA-N
SmilesOC1=CC(S(N2[C@@H](CCN3CCC(C)CC3)CCC2)(=O)=O)=CC=C1.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
phosphatebufferedsaline1.765
DMSO38.89100
water7.7820

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight388.95.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.57mL12.86mL25.71mL
5mM0.51mL2.57mL5.14mL
10mM0.26mL1.29mL2.57mL
50mM0.05mL0.26mL0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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