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Tocris/SCH 79797 dihydrochloride/1592/10/10 mg

Description:Potent,selectivenon-peptidePAR1antagoNIST
ChemicalName:N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diaminedihydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,selectivenon-peptidePAR1receptorantagonist(IC50=70nM).InhibitshaTRAP-induced-butnotγ-thrombin-,ADP-orcollagen-inducedhumanplateletaggregation.AlsoselectivelyblocksPAR1agonist-orthrombin-inducedincreasesincytosolicCa2+invascularsmoothmusclecells.

TechnicalData

M.Wt444.41
FormulaC23H25N5.2HCl
StorageDesiccateatRT
Purity≥99%(HPLC)
CASNumber1216720-69-2
PubChemID45073452
InChIKeyNNJTXSQXGHYXAJ-UHFFFAOYSA-N
SmilesCl.Cl.CC(C)C1=CC=C(CN2C=CC3=C2C=CC2=NC(NC4CC4)=NC(N)=C32)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO22.2250
ethanol11.1125

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight444.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.25mL11.25mL22.5mL
5mM0.45mL2.25mL4.5mL
10mM0.23mL1.13mL2.25mL
50mM0.05mL0.23mL0.45mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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