JPT/A2T-Beta-Amyloid (1-40); HFIP treated (0.5mg)/SP-Ab-28_0.5/

A2T-Beta-Amyloid(1-40);HFIPtreated(0.5mg)

ProductCode:SP-Ab-28_0.5

VariantofhumanAbeta(Amyloidbeta)1-40peptide,whereAla2isreplacedbyaThreonine(Thr)(Swiss-ProtID:P05067).HFIPtreatmentisperformedtodisruptβ-sheetandotherunwantedsecondarystructures.
AminoAcidSequence:DTEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Proteinname:Amyloidbeta(A4)(alternativenames:Abeta,Betaamyloid,APP)
Amount:1vial(0.5mg)
Purity:>95%(HPLC-MS)
DeliveryFormat:Freezedriedinplasticvials
Application(s):Invitrostaining,Bindingexperiments
Indication(s)/Topic(s):Neurodegenerativedisease,Alzheimer’sdisease
DeliveryTime:2-5days

JPT"sAmyloidBetaA4Peptides(ABetaPeptides)
JPTPeptideTechnologieshassubstantial,long-standingexpertiseinprovidingpeptides,peptidomimetics,andproteinstotheglobalscientificcommunity.Ourhighlyskilledandcommittedscientificstaffensuresthatthemostappropriatemethodsandtechniquesareselectedforeverysynthesisproject.AllofJPT"scatalogpeptidesareprovidedwithHPLC-MSanalysestoconfirmtheidentityanddemonstratethehighqualityofourpeptides.

BenefitsofJPT"sAmyloidBetaA4Peptides(ABetaPeptides)
-WholeproductionperformedinaregulatedEuropeanenvironmentaccordingtoDINENISO9001:2015&GCLPstandards;Auditswelcome!
-ProvidedasHFIP-filmstoguaranteechemicallyandstructurallyhomogenousmaterialwithoutanyunwantedsecondarystructures
-GreatestvarietyofAbetasequencemodificationsinstock-availablewithindays!
-ProvisionoffreezedriedaliquotsforenhancedstABIlity
-Notfoundwhatyouarelookingfor?Requestaquoteforcustompeptidesynthesis

A2T-Beta-Amyloid(1-40);HFIPtreated(0.5mg)

SelectedReferences
"CompetitiveMirrorImagePhageDisplayDerivedPeptideModulatesAmyloidBetaAggregationandToxicity"
Rudolphetal.,PLoSOne. (2016)-PMID:26840229
"InhibitionoftheCardiacNa+Channelα-subunitNav1.5byPropofolandDexmedetomidine"
Stoetzeretal.,NaunynSchmiedebergsArchPharmacol.-PMID:26667357
"Aβ-42loweringAgentsFromtheMarine-DerivedFungusDichotomomycesCejpii"
Harmsetal.,Steroids.(2015)-PMID:26440473
"η-SecretaseProcessingofAPPInhibitsNeuronalActivityintheHippocampus"
Willemetal.,Nature(2015)-PMID:26322584
"HybridizationofanAβ-specificAntibodyFragmentwithAminopyrazole-basedβSheetLigandsDisplaysStrikingEnhancementofTargetAffinity"
Hellmertetal.,Org.Biomol.Chem.(2015)-PMID:25613910

ApplicationNote
"SyntheticAmyloidBetaPeptidesAidAlzheimerInvestigation"
Broersenetal.,ApplicationNote(2013)(fulltext)

Testimonial
"OurgroupfocusesontheinvitrostudyofriskfactorsinAlzheimer’sdiseaseand,asweexperiencedthatthein-houseexpressionandproductionoftheamyloidbetapeptideisnotoriouslydifficult,wearecontinuouslydependentonahighqualitysupplyofalargevarietyofthesepeptidesfromcommercialsource.WestartedourcollaborationwithJPTwiththeirrequesttotestarangeoftheirpeptidesfortheabilitytoproducetoxicoligomersandfibrillarnetworksandwereimpressedbytherapidsupplyofaverywiderangeofhighpuritypeptideswithexcellentfibrilformingpropertiesandtoxicityprofiles.JPThasshownrealvaluableknow-howandexperienceinthefieldofpeptidesynthesisbytheirabilitytogeneratehighqualitypreparationsofamyloidbetapeptidevariantswhichareknownfortheirdifficultytohandle."
KerensaBroersen,AssistantProf.,NanobiophysicsGroup,UniversityofTwente,Enschede,TheNetherlands

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