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JPT/NB Histone Peptide H3 23:39 K27me3_K36me1 (H3.12)/SPHis_nb_105/

NBHistonePeptideH323:39K27me3_K36me1(H3.12)

ProductCode:SP-His_nb_105

SyntheticHistonepeptidecarrying2modifications(K27me3,K36me1)derivedfromhumanHistoneH3.12(Swiss-ProtIDs:Q71DI3,P68431).
Aminoacidsequence:H-KAAR-Lys(Me3)-SAPATGGV-Lys(Me)-KPH-NH2
Amount:1vialcontaining30nmol(approx.100µg)
Purity:>70%(HPLC-MS)
Deliveryformat:Freeze-driedinambertypeglassvials
Application(s):Enzymekinetics,SubstrateSpecifity,Substrateidentification,Competitionexperiments,Co-crystallization,NMRstudies
Indication(s)/Topic(s):Cancer,Kinase,Methyltransferase,Acetyltransferase,Histones,Phosphatase,Generegulationandexpression,Epigenetics,Cellsignaling,Nucleosome
Deliverytime:10-12days

JPTsNon-BiotinylatedHistoneCodePeptides
Inadditiontoourbiotinylatedhistonepeptides,JPToffersanon-biotinylatedlibraryofsyntheticposttranslationallymodifiedandunmodifiedhumanhistonepeptidesthatisnowavailableasindividualpeptides.Thepeptidelibraryconsistsof160peptidesfromdifferenthistonefamilies.PeptidescarryPTMsatreportedsites(e.g.acetylation,methylation,phosphorylation...)invariouscombinationsrepresentingnaturalvariants.
JPTshighlyskilledandcommittedscientificstaffensuresthatthemostappropriatemethodsandtechniquesareselectedforeverysynthesisproject.AllofJPTscatalogpeptidesareprovidedwithHPLC-MSanalysestoconfirmtheidentityanddemonstratethehighqualityofourpeptides.

BenefitsofJPTsHistoneCodePeptides
-WholeproductionperformedinaregulatedEuropeanenvironmentaccordingtoDINENISO9001:2015&GCLPstandards;auditswelcome!
-Forhigh-throughputscreeningJPTsHistoneCodePeptideMicroarrayisavailabledisplayingmorethan3000peptides.
-Provisionoffreezedriedaliquotsforenhancedstability
-Proventrackrecordformanyapplications

NBHistonePeptideH323:39K27me3_K36me1(H3.12)

SelectedReferencesforHistonePeptideTools
"HistoneH2AandH4N-TerminalTailsarePositionedbytheMEP50WD-RepeatProteinforEfficientMethylationbythePRMT5ArginineMethyltransferase"
Burgosetal.,J.Biol.Chem.(2015)-PMID:25713080
"H3K23me2isaNewHeterochromaticMarkinCaenorhabditiselegans"

Vandammeetal., NucleicAcidsRes.(2015)-PMID:26476455
"StructureoftheArginineMethyltransferasePRMT5-MEP50RevealsaMechanismforSubstrateSpecificity"
Hoetal.PLOSONE(2013)-PMID:23451136
"UseofHigh-DensityHistonePeptideArraysforParsingtheSpecificityofaHistone-ModifyingEnzymeComplex"
Shechteretal,ApplicationNote(2013)(fulltext)
"ComprehensivePeptideMicroarraysforHistoneResearch"
Schnatbaumetal,32thEPS(2012)(fulltext)

ApplicationNotes
"UseofHigh-DensityHistonePeptideArraysforParsingtheSpecificityofaHistone-ModifyingEnzymeComplex"
Shechteretal.ApplicationNote(2013)(fulltext)
"ComprehensiveCharacterizationofAntibodiesDirectedtowardsEpigeneticHistone-Modifications"
Maschetal.ApplicationNote(2015)(fulltext)

TestimonialforHistoneCodePeptideMicroarray
"JPTsnewextremelyhigh-densityhistonepeptidearrayisadramaticleapforwardforanalysisofthehistonecodehypothesis.Thecompletesequencecoverageacrosscorehistonesandhistonevariantsaswellasthepresenceofcommonandrarehistonepost-translationalmodifications "aloneandincombination"makesthisanunparalleledtoolforstudyingthe"writers"and"readers"ofthehistonecode.MylaboratoryhasusedthesearraystoaskthesequenceandPTMdependenceofahistonewriterenzymeandwehavediscoveredanactivityspecifyingcodethatwillkeepusbusyforyearstocome."
DavidShechter,PhD,DepartmentofBiochemistry,AlbertEinsteinCollegeofMedicine,YU(NY,USA)

NBHistonePeptideH323:39K27me3_K36me1(H3.12)

TechnicalData:
HistoneFamilyHistoneH3
Modification2Modifications
SequencePositionTail(1-42)
IsoformH3.1
H3.2
BiotinylationNoBiotin
ApplicationSubstrateidentification
ProteinNameHistones
OrganismHomosapiens(Human)
Indication/TopicAcetyltransferase
Epigenetics
Kinase
Numberofpeptides

FurtherInformation:
Amount1vialcontaining30nmol(approx.100µg)
SpecificationsSyntheticHistonepeptidecarrying2modifications
DocumentationProductDatasheet
Swiss-ProtID
Q71DI3, 
P68431
NCBI
SequenceH-KAAR-Lys(Me3)-SAPATGGV-Lys
(Me)-KPH-NH2

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