JPT/SpikeMix™ Cytokines (Zebrafish) heavy/SPTCYTPOOLLzeb/

SpikeMix™Cytokines(Zebrafish)-heavy

ProductCode:SPT-CYT-POOL-L-zeb

Poolof109stableisotope-labeledproteotypicpeptidesforZebrafishcytokines(e.g.interleukines,intereferons,lymphokines).Stableisotopelabeledpeptidemixtureforrelativequantificationbymass-spectrometrybasedproteomics(MRM,SRM).
Amount:1vialwithapoolof109stableisotopelabeledproteotypicpeptides(50-150pmolperpeptide)
DeliveryFormat:Poly-propylenevial
Application(s):SRMassays,MRMassays,Proteomics,CancerbioMarkerresearch
Indication(s)/Topic(s):Generegulation&expression,Cancer,Breastcancer,Burkittslymphoma,Gastriccancer,Testis/ovarycancer,Cancerchemotherapy,Melanoma,Prostatecancer,Alzheimersdisease,Majordepression
DeliveryTime:2-5days

JPTsSpikeMix™Cytokines
JPTproducedspeciesspecificmixturesofproteotypicpeptidesforthedetectionofthe mostrelevantcytokinesbymass-spectrometrybasedproteomics.Cytokinesareimmunomodulatingagents,suchasinterleukins,lymphokines,monokines,colonystimulationgfactors,chemokinesandinterferons.Theyareregulatorsofhostresponsestoinfection,immuneresponses,inflammation,andtrauma.Thismixedpeptidesareavailableasstableisotopelabeledpeptides(usingheavyArgU-13C6,U-15N4orLysU-13C6,U-15N2).

BenefitsofJPTsSpikeMix™Cytokines
-Quantificationofmultiplecytokinesfromasinglesample(e.g.IFN,IL-1,IL-2,IL-10,TNF,TGF)
-Economicpremixedheavypeptidesetsavailablefordifferentspecies
-Multiplexedanalysisofdiseasestatusandtherapeuticsuccess

SpikeMix™Cytokines(Zebrafish)-heavy

SelectedReferences
"QuantitativeProteomicsofBronchoalveolarLavageFluidinIdiopathicPulmonaryFibrosis"
Fosteretal.,JofProteomeResearch(2015)-PMID:25749006
"BiomarkerDevelopmentforIntraductalPapillaryMucinousNeoplasmsUsingMultipleReactionMonitoringMassSpectrometry"
Kimetal.,J.ProteomeRes(2015)-PMID:26561977
"DevelopmentandValidationofaNovelPlasmaProteinSignatureforBreastCancerDiagnosisbyUsingMultipleReactionMonitoring-basedMassSpectrometry"
Leeetal.,AnticancerResearch(2015)-PMID:26504062
"Non-invasivePrognosticProteinBiomarkerSignaturesAssociatedwithColorectalCancer"
Surinovaetal.,EMBOMolMed.(2015)-PMID:26253080

ApplicationNotes
"DevelopmentofaMultiplexedTargetedSRMAssayforNCI’sTopTumorAssociatedAntigens"
Soderblometal.,ApplicationNote(2015)Fulltext
"AbsoluteQuantificationofMetabolicEnzymesviaTargetedProteomicsusinganewKitofSpikeTides™Peptides"
Bindeletal.,ApplicationNote(2015)Fulltext
"DevelopmentandCharacterizationofSpikeMix™ABRF(cross-SpeciesStandard)Consistingof1,000StableIsotopeLabeledPeptides"
Colangelo,ApplicationNote(2014)Fulltext

Testimonials
"AsDirectoroftheProteinProfilingatYaleKeckBiotechnologyResourceFacility,IcoordinatedacollaborationbetweentheAssociationofBiomolecularResourceFacilities(ABRF)standardproteomicresearchgroup(sPRG)andJPTPeptideTechnologiestodeveloptheABRFcross-speciesSpikeMix™peptidepool.Thejointdevelopmentturnedouttobeanextraordinaryeffectiveendeavorandtheresultingproductwasqualifiedinmorethan52proteomicslabsaroundtheglobe.IwasimpressedbyJPTsscientificandtechnologicalcapabilitiesaswellastheirenthusiasmtodrivetheprojectforward."
ChristopherM.Colangelo,DirectorofProteinProfilingatKeckBiotechnologyResourceFacility,YaleUniversity,USA

"OurresearchatStanfordUniversityseekstodiscoverunconventionaltranslationproducts,andproteinsmadebyunsequencedorganisms;tocharacterizeawidearrayofproteinpost-translationalmodifications;andtoperformpeptideantigenbindingassays.Onallofthesefronts,weareinneedofhighqualitypeptidestandardsforassaydevelopmentandproteinquantification.ThesuccessfulcollaborationwiththeteamatJPTPeptideTechnologiesandtheirwiderangeofproductshasbeenacriticalfactorforadvancingmygroupsresearch."
JoshuaE.Elias,Ph.D.,AssistantProfessor,Chemical&SystemsBiology,StanfordUniversitySchoolofMedicine,ClarkCenter,Stanford,CA