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Discovery Antibodies/(S)-AMPA/10 mg/A-267-10 mg

Cat#:A-267
AlternativeName(S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicacid
  • LyophilizedPowder
  • BioassayTested
    • SourceSynthetic
    MW:186.17
    Purity:>99%(HPLC)
    Effectiveconcentration0.01-10µM.
      • (S)-AMPA
    Chemicalname(2S)-2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoicacid.
    MolecularformulaC7H10N2O4.
    CASNo.:83643-88-3.
    PubChemCID158397
    ActivityAnactiveenantiomerofAMPA(EC50 =3.5 μM)1.
      • Falch,E. etal. (1998)J.Med.Chem. 41, 2513.
    ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.
    Solubility100mMinH2O.Centrifugeallproductsbeforereconstitution(10000xg5min).
    StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.Itisrecommendedtoaliquotreconstitutedstocksolutions.
      • (S)-AMPA
        AlomoneLabs(S)-AMPAactivatesGluA1channelsexpressedinXenopusoocytes. 
        Timecourseofcurrent,reversIBLyactivatedby1µMand10µM(S)-AMPA(#A-267)asindicated,whilemembranepotentialwasheldat-80mV.
    References-Scientificbackground
    • 1.Falch,E. etal. (1998)J.Med.Chem. 41, 2513.
    • 2.Guntupalli,S.etal.(2016)Neural.Plast. 2016,3204519.

      • (S)-AMPAenantiomerisasyntheticAMPAreceptoragoNIST.Thecompoundmimicstheeffectsoftheglutamateneurotransmitter1.

        IonotropicglutamateAMPAreceptors(AMPARs)aretheprimaryreceptorsthatmediatefastexcitatorysynaptictransmissioninthemammalianbrain.Themajorityofthistransmissioninthemammaliancentralnervoussystemismediatedbythereleaseofglutamatefromthepresynapticterminalanditsbindingtoglutamatereceptorsonthepostsynapticmembrane2.

    TargetAMPAreceptors
    LyophilizedPowder
    receivea1mgfreetrialsample!
    Lastupdate:13/10/2019

    (S)-AMPA(#A-267) isahighlypure,synthetic,andbiologicallyactivecompound.

    Forresearchpurposesonly,notforhumanuse
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