Deprecated: Creation of dynamic property cls_session::$session_data_table is deprecated in /www/sites/www.188bio.com/index/systems/cls_session.php on line 49
Discovery Antibodies/CX 546/10 mg/C-210-10 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
您好,欢迎您进入188进口试剂采购网网站! 服务热线:4000-520-616
蚂蚁淘商城 | 现货促销 | 科研狗 | 生物在线
产品资料

Discovery Antibodies/CX 546/10 mg/C-210-10 mg

Cat #: C-210
  • Lyophilized Powder
  • Bioassay Tested
    • Source Synthetic
    MW: 247.3
    Purity: >99%
    Form Lyophilized powder.
    Effective concentration 10-630 µM.
      • CX 546
    Chemical name (2,3-dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone.
    Molecular formula C14H17NO3.
    CAS No.: 215923-54-9.
    Activity CX 546 is a selective AMPA receptor agonist1.
      • Nagarajan, N. et al. (2001) Neuropharmacology 41, 650.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 126 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
      • CX 546
        Alomone Labs CX 546 potentiates GluA1 channels expressed in Xenopus oocytes.
        Time course of current reversible potentiation by 12.6, 126 and 630 μM CX 546 (#C-210) of glutamate-elicited currents (100 μM, holding potential -80 mV).
    References - Scientific background
    • 1. Arai, A. and Lynch, G. (1998) Brain Res. 799, 235.
    • 2. Arai, A.C. and Kessler, M. (2007) Curr. Drug Targets 8, 583.
    • 3. Nagarajan, N. et al. (2001) Neuropharmacology 41, 650.

      • The AMPAkine families of drugs are positive allosteric modulators of AMPA receptors in the mammalian brain. These compounds facilitate learning and memory in both humans and animals. Positive modulation of AMPA receptors by AMPAkines can improve channel function by increasing receptor sensitivity to endogenous ligands and specific agonists1.

        The AMPAkine 1-(quinoxalin-6-ylcarbonyl)-piperidine (CX546) is a brain-penetrating compound, which facilitates AMPA receptor-mediated transmission. CX546 has an EC50 in a hippocampal slice preparation of 150 μM as measured by patch clamp in cultured hippocampal neurons. The action of CX546 on AMPA receptor transmission results in memory enhancement, which has been demonstrated in rodents, primates, and humans2.

        Recent findings now indicate that CX546-mediated AMPA receptor enhancement strengthens neuronal survival signaling, leading to concomitant reduction in hippocampal damage3.

        CX546 was researched as a treatment for Alzheimer"s disease under the brand name Ampalex.

    Target AMPA receptors
    Lyophilized Powder
    receive a 5 mg free trial sample!
    Last update: 13/10/2019

    CX 546 (#C-210) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    相关产品

    SouthernBiotech/Goat Anti-Human Lambda-Alexa Fluor® 555/2070-32/1.0 mg

    vectorlabs/Biotinylated Aleuria Aurantia Lectin (AAL)/B-1395/1 mg

    vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Mouse IgG)/PK-6102/1 kit

    vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Universal)/PK-6200/1 kit

    vectorlabs/Unconjugated Musa Paradisiaca (Banana) Lectin (BanLec)/L-1410/5 mg

    GiottoBiotech/Calmodulin N60D/5 mg/G02CLM60cn

    TriLink/Modification Buffer (10X)/S-4000/5 x 1.5 mL

    TriLink/S-4FB Crosslinker (DMF Soluble)/S-1004/5 x 1 mg

    最新签约

    Altogen

    Accelagen

    SBI

    anchormolecular

    Echelon

    ProChimia

    Lifespan

    Bioclone

    技术文章

    ProChimia/HS(CH2)mCOOH/FT 002m101/1 g

    杭州Enzymatics inc批发，产品货源 Enzymatics T4连接酶

    恭喜蚂蚁淘生物成功获得Matriks Biotek®抗体国内代理权！ 招商信息 资讯 蚂蚁淘在线

    银川Enzymatics代理，产品目录 Enzymatics超纯连接酶

    Liposoma代理，产品目录 liposoma对照脂质体

    Anatrace/F306PDH FosCholine11Per Deuterated Head/ F306PDH 100 MG/ 100 mg

    Alomone Labs Anti Human C5aR1 extracellular Antibody AAR 032代理价格

    p53NtermTrap | Chromotek

    新闻动态

    苏州Enzymatics型号参数规格 Enzymatics超纯poly酶

    19413561 GAMMASECRETASE INHIBITOR X 1MG

    西安ProChimia抗体，试剂，血清，细胞 Prochimia Surfaces授权代理

    广州生命科学Xona microfluidics价格优惠 xona microfluidics 细胞培养皿

    西安Biotech Support Group中国试剂购买网站 BSG基因样品预处理产品

    苏州美国Xona microfluidics公司 xona microfluidics 神经元细胞

    HbC试剂盒ELISA 国内优质ELISA厂家

    天津rPeptide中国试剂购买网站 rPeptide老年性痴呆症与帕金森综合症

    行业前沿

    正品Pfenex生物试剂 重组白喉杆菌CRM197,为什么这么便宜?

    PfenexX中国代理价格，厂家 SEA133鲑鱼纤维蛋白原,求推荐!

    Pfenex中国采购 三文鱼凝血酶/鲑鱼凝血酶 Salmon Thrombin,是正品吗?

    Polysciences聚乙烯亚胺 Polyethylenimine,好用吗?

    PolysciencesX中国代理价格，厂家 Polysciences24765,哪里有卖?

    Polysciences代理，产品目录 Polysciences聚合物,是正品吗?

    Sea Run Holding产品促销 重组白喉杆菌CRM197,为什么这么便宜?

    生命科学Pfenex价格优惠 Sea Run Holding代理，产品目录,有优惠活动吗?

    最热产品

    Jackson/Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)/2.0 ml/115-035-003

    Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003

    Qubit™ dsDNA BR Assay Kit Q32853现货

    Parafilm M封口膜/PM996/4x125/整箱

    Invitrogen Q32855 Qubit™ RNA HS Assay Kit现货促销

    LUCK-1G,D-Luciferin, Potassium Salt 钾盐现货

    GoldBio/D-Luciferin, Sodium Salt (Proven and Published™)/LUCNA-1G/1 g

    Leica徕卡819一次性窄刀片【50片/盒，10盒/条】/14035838925

    推荐新闻

    RA Biosources报价单 rabios代理

    Lampire型号参数规格 Lampire公司

    品牌试剂实验Medica Lisotopes代理 Medica Lisotopes产品

    进口试剂QoolAbs直采 Qoolabs噬菌体筛选

    进口Molecular Research Center品牌清关代理 MRC一步法TRIzol RNA抽提

    授权代理商，正品 Spherefluidics授权

    Ursabioscience美元价/进货价 Ursa BioScience产品

    Wards Science抗体，试剂，血清，细胞 wardsci授权

    新闻动态
    行业前沿
    技术文章
    最新产品