CyPPA(#C-110) isahighlypure,synthetic,andbiologicallyactivecompound.
Thisproductisfreezedried.Allwatermoleculeshavebeenremoved.
Everylotistried&testedinarelevantBIOLOGicalassay.
OurBioassay
Ca2+-activatedpotassiumchannels(KCa)areagroupof6/7-TMionchannelsthatselectivelytransportK+ionsacrossbiologicalmembranes.Theyarebroadlyclassifiedintothreesubtypes:SK,IKandBKchannels(small,intermediateandbigconductance).
Small-conductanceCa2+-activatedK+channels(SKchannels)underliethemediumdurationafterhyperpolarizationthatfollowssingleortrainsofactionpotentialsinmanytypesofneurons.ThisfamilyiscomposedofKCa2.1(SK1),-2.2(SK2),and-2.3(SK3)isoforms,whichareexpresseddifferentiallywithinthecentralnervoussystem(CNS)1,2.
CyPPAisanactivatorofsmallconductanceKCa channelsthatdisplaysselectivityforSK2andSK3channels(EC50valuesare5.6and14µMforSK3andSK2respectivelyandefficacyis90%and71%forhSK3andhSK2,respectively)3.CyPPAdisplaysnoactivityatSK1andIK(KCa3.1)channels3.
CyPPAisatoolfordistinguishingSK2andSK3fromSK1andIK;nootheragentsdistinguishthesechannelsfromoneanother.Therefore,itenrichestherepertoireoftoolsavailabletotestthehypothesisthatSKchannelsmaybetargetsforfutureCNSdrugs4.
CyPPAwasfoundtoblockTRPM7channels,demonstratinganoverlapbetweenpharmacologicalcompoundsactingonTRPandKCachannels5.
CyPPA(#C-110) isahighlypure,synthetic,andbiologicallyactivecompound.
SouthernBiotech/Goat Anti-Human Lambda-Alexa Fluor® 555/2070-32/1.0 mg
vectorlabs/Biotinylated Aleuria Aurantia Lectin (AAL)/B-1395/1 mg
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Mouse IgG)/PK-6102/1 kit
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Universal)/PK-6200/1 kit
vectorlabs/Unconjugated Musa Paradisiaca (Banana) Lectin (BanLec)/L-1410/5 mg
GiottoBiotech/Calmodulin N60D/5 mg/G02CLM60cn