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Millipore/MAB5432 | Anti-CREB Antibody/MAB5432/100 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Millipore/MAB5432 | Anti-CREB Antibody/MAB5432/100 µg

Description
CatalogueNumberMAB5432
Replaces04-218
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionAnti-CREBAntibody
AlternateNames
  • cAMP-responseElementBindingProtein
BackgroundInformationCREBisabetaZIPtranscriptionfactorthatactivatestargetgenesthroughcAMPresponseelements.CREBisabletomediatesignalsfromnumerousphysiologicalstimuli,resultinginregulationofabroadarrayofcellularresponses.WhileCREBisexpressedinnumeroustissues,itplaysalargeregulatoryroleinthenervoussystem.CREBisbelievedtoplayakeyroleinpromotingneuronalsurvival,precursorproliferation,neuriteoutgrowthandneuronaldifferentiationincertainneuronalpopulations.CREBpromotesoutgrowthanddifferentiationasamediatorofNeurotrophinpathways.CREBisabletoselectivelyactivatenumerousdownstreamgenesthroughinteractionswithdifferentdimerizationpartners.CREBisactivatedbyphosphorylationatSer133byvarioussignalingpathwaysincludingErk,Ca2+andstresssignaling.
ProductInformation
FormatPurified
Control
  • Jurkatnuclearextract,A-431wholecelllysate
PresentationPurifiedimmunoglobulin.LiquidinPBScontaining0.1%sodiumazide.
StorageandShippingInformation
StorageConditionsMaintainat2-8°Cinundilutedaliquotsforupto6monthsafterdateofreceipt.
Applications
ApplicationAnti-CREBAntibodyisaMouseMonoclonalAntibodyfordetectionofCREBalsoknownascAMP-responseElementBindingProtein&hasbeenvalidatedinELISA&WB.
KeyApplications
  • ELISA
  • WesternBlotting
ApplicationNotesWesternblot:1-5μg/mL.Recognizesthe~43kDaprotein.

ELISA:0.1-1.0μg/mL

Optimalworkingdilutionsmustbedeterminedbyenduser.
BIOLOGicalInformation
ImmunogenRecombinantCREB-Aprotein.
ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
HostMouse
SpecificityReactswithCREB.
IsotypeIgG1
SpeciesReactivity
  • Human
  • Mouse
  • Rat
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryThisgeneencodesatranscriptionfactorthatisamemberoftheleucinezipperfamilyofDNAbindingproteins.ThisproteinbindsasahomodimertothecAMP-responsiveelement,anoctamericpalindrome.Theproteinisphosphorylatedbyseveralproteinkinases,andinducestranscriptionofgenesinresponsetohormonalstimulationofthecAMPpathway.Alternatesplicingofthisgeneresultsintwotranscriptvariantsencodingdifferentisoforms.
GeneSymbol
  • CREB1
  • MGC9284
  • CREB
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P16220#ThisproteinbindsthecAMPresponseelement(CRE),asequencepresentinmanyviralandcellularpromoters.CREBstimulatestranscriptiononbindingtotheCRE.
SIZE:341aminoacids;36688Da
SUBUNIT:BindsDNAasadimer.InteractsPPRC1andwithHTLV-1Tax-1.
SUBCELLULARLOCATION:Nucleus.
PTM:Stimulatedbyphosphorylation.PhosphorylationofbothSer-133andSer-142intheSCNregulatestheactivityofCREBandparticipatesincircADIanrhythmgeneration.PhosphorylationofSer-133allowsCREBBPandEP300binding(Bysimilarity).PhosphorylateduponDNAdamage,probablybyATMorATR.
SIMILARITY:SwissProt:P16220##BelongstothebZIPfamily.&Contains1bZIPdomain.&Contains1KID(kinase-inducIBLe)domain.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
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