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Manipulatereceptorandenzymefunctionwith
inhibitors,activators,agoNISTsandantagonists.

Enzymeinhibitors andactivators		Receptoragonists andantagonists		Ionchannelblockers andmodulators

>Clathrin >CAMK >AMPK >HDAC >Rho	>MAPK >Caspase >PI3K/Akt >ATPase	>Glutamate >GPCR >Muscarinic >Adenosine >Adrenoceptors	>GABA >Nicotinic >Purinergic >SEROtonin	>Sodium >Calcium >Ionophores >Chelators	>Potassium >TRP >Indicators

Advantagesofsmall-moleculeinhibitors

Lowcompromiseto protein-proteininteractions	Rangeofselectivity	Rapideffectsfortemporalcontrol

Cell-permeableandblood-brain barrierpermeableoptions	ReversIBLeandlong-termeffects	Easytouse

	Qualityguaranteed	Highpuritycompounds	Technicalsupport

Guidelinesforsmall-moleculeinhibitors
1. Checkpublications foraninsightintoselectivity,potencyadvantagesanddisadvantagesofchoseninhibitorsinyoursystem 2.Alwayscheckthereisa rationalcorrelation betweenbiochemicalinhibitioninvitroandeffectiveinhibitionincells
3.Ideallyyoushoulduseaninhibitoratthe lowestconcentration inordertominimizeoff-targeteffects 4.Whereavailableuse multipleinhibitors toyourtargetofinterestinparallelexperimentsto backupyourobservations 5.Whereavailable,use positiveandnegativecontrols 6.Ifpossibleruleoutoff-targeteffectsbyusing drug-resistant models

Studyreceptorandsignalingpathwayswithourexceptionalqualityrangeincluding:

Enzyme&Signalinginhibitors&activators

ProductName	Description	Citations	Purity	Productcode
Y-27632dihydrochloride	SelectiveRhokinaseinhibitor	13	>99%	ab120129
Pitstop2™	Novel,selectivecell-permeableclathrininhibitor	14		ab120687
AmyloidβPeptide(1-42)(human)	Predominantamyloid-βproteinfragment	2	>95%	ab120301
Z-VAD(OMe)-FMK	Cell-permeable,irreversiblepan-caspaseinhibitor		>90%	ab120487
(±)-Blebbistatin	Potent,selectiveinhibitorofmyosinII	1	>98%	ab120425
FK506(Tacrolimus)	Immunosuppressant	1	>98%	ab120223
FCCP	Mitochondrialoxidativephosphorylationinhibitor	2	>99%	ab120081
Doxorubicinhydrochloride	TopoisomeraseIIinhibitor.Antibioticwithcytotoxicactions.		>98%	ab120629
NKH477(Colforsindaropate)	Adenylylcyclaseactivator		>98%	ab120190
A769662	AMP-activatedproteinkinaseactivator	2	>99%	ab120335
Forskolin	Adenylylcyclaseactivator	5	>98%	ab120058
Dyngo-4a™	Novel,highlypotentdynamininhibitor	5		ab120689
SL327	MEKinhibitor	6	>99%	ab120082
SB431542	ALKinhibitor	3	>99%	ab120163
DAPT	γ-secretaseinhibitor	2	>99%	ab120633
Dynasore	Cell-permeabledynamininhibitor	7	>99%	ab120192
Phorbol12-myristate13-acetate(PMA)	PKCactivator	3	>99%	ab120297
AICAR(Acadesine/AICAriboside)	Cell-permeableactivatorofAMP-activatedproteinkinase		>98%	ab120358
Z-VAD-FMK	Irreversiblegeneralcaspaseinhibitor	1	>98%	ab120382
Okadaicacid	PP1andPP2Ainhibitor	2	>98%	ab120375
STO-609	Potent,competitive,selectiveandcell-permeableinhibitorofCaM-KK		>98%	ab141591
BafilomycinA1	Highlypotent,selective(V)-ATPaseinhibitor	4	>98%	ab120497

Ionchannelmodulators

ProductName	Description	Citations	Purity	Productcode
Tetrodotoxincitrate	Na+channelblocker;water-soluble	26	>98%	ab120055
Tetrodotoxin	Na+channelblocker	88	>98%	ab120054
QX-314bromide	Na+channelblocker	8	>99%	ab120117
IonomycinCa2+Salt	Ca2+ionophore	2	>99%	ab120116
BAPTA-AM	SelectiveCa2+chelator		>98%	ab120503
Ionomycin(freeacid)	Ca2+ionophore	2	>99%	ab120370
SNX482	R-TypeCa2+(Ca_v 2.3)channelblocker	1	>96%	ab120259
ω-ConotoxinGVIA	Ca2+channelblocker(Ntype)	3	>96%	ab120215
Veratridine	Na+channelopener	1	>97%	ab120279
HC-030031	TRPA1blocker,orallyactive		>99%	ab120554
TertiapinQ	PotentinwardrectifierK+channelblocker	1	>99%	ab120432
Iberiotoxin	Selectiveblockerofthehigh-conductance,Ca2+-activatedK+channel	1	>95%	ab120379
Capsazepine	VR1antagonist	6	>99%	ab120025
Apamin	BlockerofsmallconductanceCa2+-activatedK+channels	2	>95%	ab120268
SKF96365	BlockerofTRPcationchannels.InhibitscapacitativeCa2+entry.	3	>99%	ab120280
KB-R7943	NCXinhibitor.TRPCblocker.		>99%	ab120284
Fura-2AM	SelectiveCa2+chelator;fluorescentindicator		>95%	ab120873
L-cis-Diltiazem	Selectivecyclicnucleotide-gatedchannelblocker		>98%	ab120532
Psalmotoxin-1	Potent,selectiveASIC1ablocker	1	>95%	ab120483
E-4031dihydrochloride	HERGK+channelblocker	1	>99%	ab120158
CharyBDotoxin	K+channelblocker	3	>98%	ab120269
(±)-BAYK8644	PotentL-typeCa2+channelactivator		>99%	ab120366

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