WholeIgGantibodiesareisolatedasintactmoleculesfromantiserabyimmunoaffinitychromatography.TheyhaveanFcportionandtwoantigenbindingFabportionsjoinedtogetherbydisulfidebondsandthereforetheyaredivalent.Theaveragemolecularweightisreportedtobeabout160kDa.ThewholeIgGformofantibodiesissuitableforthemajorityofimmunodetectionproceduresandisthemostcosteffective.
Aliquotandfreezeundilutedproductat-20°Corbelow.Avoidrepeatedfreezingandthawing.Prepareworkingdilutionfresheachday.
Expirationdate:sixmonthsfromdateofreceipt.However,theexpirationdatemaybeextendediftheproductisstoredaccordingtotherecommendationandthetestresultsareacceptableforitsintendeduse.
Colloidalgoldreagentsfortransmissionandscanningelectronmicroscopy(EMGrade)aredistinguishedfromothercommercialpreparationsbycarefulseparationofmonomericparticlesfromsmallaggregatesusingultracentrifugationindensitygradients.Theresultingmonomericcolloidalgold-proteincomplexesaresuspendedinsterile-filteredbuffercontainingstabilizersandapreservative.AllparticlesizesintheEMGradecategorymayalsobeusedforlightmicroscopyandimmunoblottingbythosewhoprefertouseparticleslargerthan4nm.