PNA probes hybridize to target DNA with high sensitivity and specificity mainly due to electricalneutrality of its chemical structure. This trait enables PNA probes to be more efficient and useful in applying to FISH (fluorescent in situ hybridization) even at low concentrations. Hybridizationoccurs fast (within a couple of hours) and background noise is reduced significantly.PNA Bio offers telomere, centromere, and CAG repeat probes as catalog itmes. If you need custom detection, we can provide custom PNA probe synthesis service. TelC is C-rich a telomere probe for a leading strand (repeats of TAACCC) and TelG isa G-rich telomere probe for lagging strand (repeats of TTAGGG). Both work with human, mouse and rat chromosomes. CENPB probe is a binding site for centromere protein B (CENP-B), one of the major centromere specific proteins. The probe sequence is ATTCGTTGGAAACGGGA, and it stains minor satellite of all human and mouse centromere except Y chromosome. Cent probe is specific for human alpha satellite centromere and does not react to mouse. The sequence of the probe is AAACTAGACAGAAGCAT. For FISH protocol using PNA FISH probes, please download following file.
SouthernBiotech/Goat Anti-Human Lambda-Alexa Fluor® 555/2070-32/1.0 mg
vectorlabs/Biotinylated Aleuria Aurantia Lectin (AAL)/B-1395/1 mg
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Mouse IgG)/PK-6102/1 kit
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Universal)/PK-6200/1 kit
vectorlabs/Unconjugated Musa Paradisiaca (Banana) Lectin (BanLec)/L-1410/5 mg
GiottoBiotech/Calmodulin N60D/5 mg/G02CLM60cn