CompanyProChimiaSurfacesisaprivatelyheldcompanyestablishedin2001andlocatedinGdanskarea,Poland.Capitalizingoninterdisciplinaryexpertiseinthefieldsofchemistry,nanotechnology,andbiotechnology,ProChimiadeliversstate-of-the...
DescriptionThemostcommonlyusedthiolsforthepreparationofadsorption-resistantSAMsongoldorothermetals(e.g.,Ag,Pd,Cu).Idealasbio-inertbackgroundincellpatterning/spreADIngstudies(Chenetal.Science276,1425,1997),SPRexperiments(Mrksich&WhitesidesAnn.Rev.Biophys.Biomol.Struct.25,55,1996,Lahirietal.Langmuir15,7186,1999),proteinmicroarrays(Schaeferlingetal.Electrophoresis23,3097,2002)andmore.
ResistivitytoproteinadsorptionissimilarfordifferentnumbersofEGunits.Ostunietal.(Langmuir17,5605,2001)reportedtheproteinadsorptivityof0.2%ML(percentmonolayer)forpureEG3SAM.Formixed1:1EG/COOHSAMs(cf.Cat.#TH003)theadsorptivitieswere:(i)fibrinogen,1.6%MLforEG3and0.4%MLforEG6(ii)Lysozyme,1.0%MLforEG3and1.0%MLforEG6.Monolayerspreparedfromourthiolshaveevenbettercharacteristicswith(~0.1%MLforpureEGnmonolayers).
OneofthemostexcitingapplicationsofEGthiolsisinthepreparationofsubstratesforcellpatterning.Thisiscommonlydonebyfirstmicropatterning(eitherbymicrocontactprintingortheASOMICtechnique;cf.schemebelowandalsoKandere-Grzybowskaetal.NatureMethods2,739,2005)anarrayofcell-adhesiveislandsofdesiredshapesanddimensions,andthenincubatingtherestofthesurfacewithanadhesion-resistantEGthiol.Whencellsareappliedontosuchasurface,theystickonlytotheislandsandassumetheirshapes.Inthisway,populationsofcellsofminimalheterogeneityareprepared,andtheinfluenceofgeometryoncellfunctioningcanbestudiedinquantitativedetail.Intheirseminalpaper(C.S.Chenetal.Science276,1425,1997),WhitesidesandIngberhaveshownhowshapemodificationcancontrolapoptosis.Morerecently(NatureMethods2,739,2005),BorisyandGrzybowskigroupshavedemonstratedhowitcanbeusedtoadjustandcontrolcytoskeletalfunctionsinlivingcells.ThepicturebelowprovidesacolorfulillustrationofthiscapABIlity,withaB16F1cellmadetriangularandthenfluorescentlylabeledformicrotubules(green),actinstressfibers(blue)andfocaladhesions(red).
Notes:(1)ThekeytosuccessfuluseofEGmonolayersforcellstudiesistheirlowcytotoxicity.ProChimiadevelopedspecialpurificationmethodstoensurethatitsthiolsareextremely"cellfriendly".(2)Formaximalcontrastbetweenthecellislandsandthebioresistantportionofthesurfacesurroundingtheseislands,werecommendtheEG6thiol.(3)PleasenotethatasofMay2006,ProChimiaalsooffersaselectionofhigh-qualitygoldsubstratesandPDMSstampsforcellmicropatterning.Pleasecontactoneofourofficestolearnaboutspecificproducts.
ProChimiaSurfacesisaprivatelyheldcompanyestablishedin2001andlocatedinGdanskarea,Poland.Capitalizingoninterdisciplinaryexpertiseinthefieldsofchemistry,nanotechnology,andbiotechnology,ProChimiadeliversstate-of-the-artsolutionsforchemicalandbiochemicalmodificationofvarioustypesofsurfacesandmaterials.Ourbusinesshasthreemaincomponents:(i)Wedevelopandmarketchemicalsforfunctionalizedself-assembledmonolayers.Ourselectionistrulyunique,andthecompoundswedesigncanbeusedtomodifymetals(gold,silver,platinum,copper,etc.),glass,silicon,oxide,orcompositesurfaces.Thethiols,dithiols,dithiolanes,silanes,catecholsandcouplingreagentsweprovidearerigorouslytestedforpurityandefficiency.TheSAMs(Self-AssembledMonolayers)formedbyourchemicalsimpartthesurfacesbeingcoatedvariouspropertiesincludingbioresistancetonon-specificbindingofproteinsorcells,reactivitytowardspecificmolecules,controlledhyrdophobicity,electrochemicaloropticalactivity,switchability,andmore.(ii)Wedevelopandmarketaselectionofmonodispersemetal(Au,Ag,Cu,Pt,Pd)andironoxidenanoparticlesfunctionalizedwithvariousligands:charged,pH-sensitive,biospecific,etc.(pleasevisitourNanoparticleBoutique)(iii)Weoffercomprehensivecustomresearchservices(linkdoSERVICES)inthefieldsofchemical-andnano-synthesis.Weworkcloselywithourclientstoensurethattheirscientificneedsarefullymet.Ourfacilitiesdedicatedtonano-compositeproductionandRenewableEnergyResearchandDevelopmentarelocatedatPPNT(PomeranianScienceandTechnologyPark)inGdynia.ProChimiaTeamProChimiaateamofexperiencedandenthusiasticchemists,chemicalengineers,biochemistsandgeneticists.OurscientistsareamongthebestinCentralEurope.EveryPh.D.onourteamhasatleasttwoyearsofpost-doctoralexperienceinrenownedUSorEUinstitutions.OurtechniciansallboastM.Sc.degrees.Weemployonlythemostaccomplishedandmotivatedscientists.AttractingtalentfromleadingacademicinstitutionsinPolandispossiblebecausewecreateanintriguingandstimulatingenvironmentforprofessionalandpersonalgrowth.OurCustomersOurproductsareusedbyover2,000organizationsworldwideinfieldsrangingfromchemistryandmaterialscience,throughmoleculardiagnosticsandbiosensors,tomicro-andnanotechnology.Thelistofourclientsincludesprestigiousacademicinstitutions(Harvard,MIT,Stanford,Berkeley,Oxford,ETH,etc.)aswellastheleadinghi-techcompanies(Intel,Fuji,IBM,Qiagene,andmore...ResearchProjectsWehaveovera10-year-longexperienceinreaserchprojectmanagementandperformnacebothprivatelyandexternallyfunded.OurscientistssuccesfullyruntheresearchfundedbyEuropeanComissionunderthe7FrameworkProgrammeandHorizon2020researchandinnovationinitiatives,including:-"Sustainableandintegratedproductionofliquidbiofuels,bioenergyandgreenchemicalsfromglycerolinbiorefineries"(GLYFINERY-7FP,2008-2012).Thisinternationallargecooperativeprojectcombinedourexpertiseinsurfaceengineeringwithresearchonrenewableenergysource.OurresearchgeneratedprotectedIPadressingthepurificationofbio-fuelsandrecoveryof"greenchemicals"producedfrombiomass;-"Nanofacturing-TheDevelopmentofMedium-andLarge-ScaleSustainableManufacturingProcessPlatformsforClinicallyCompliantSolidCoreNanopharmaceuticals"(NANOFACTURING-HORIZON2020,2015-2018).TheprojectisastepaheadfortheGMPprocessdevelopmentandmanufacturingofnanopharmacueticals,aimedattheefficaciousandcosteffectivemanufactureofgoldcorenanoparticlescoupledwithAPIsforclinicaluseandsuccessfuladministrationinhumansbothclinicalandultimatelycommercialscale.
苏州蚂蚁淘生物科技有限公司是一家创新型高科技生物公司，以常规生物学实验外包与生物学试剂为基础，放眼于生命科学领域的前沿技术服务，公司技术骨干有着多年的生物学科研背景，毕业于国内外名牌大学，并且有着丰富的项目经验，了解国内外科研行情，我公司力求为每一个客户提专业、针对性的实验方案。我公司以技术服务为支点，和国内外多家生物试剂公司有着密切的业务往来.公司特色技术服务包括：抗体药物研发、噬菌体抗体库、蛋白表达与传化、抗体制备、高通量测序、组学研究、生物信息学分析与方法建立、基础分子生物学技术外包、化学中间体合成、原料药物研发、论文编写等。我公司秉承”诚信做人，认真做事，服务至上“，希望用我们的专业知识和项目经验为国内科研客户解决科研问题，祝您科研之路畅通无阻！
ProchimiaSurfaces授权代理进口代理全国代理一级代理苏州蚂蚁淘-代理销售波兰ProchimiaSurfaces公司的产品
ProchimiaSurfaces波兰ProChimia成立于2001年。专注于化学领域、纳米技术和生物技术领域，ProChimia为化学和生化各种类型的表面和材料的改性提供了一流的解决方案。产品用于官能化自组装单分子膜的化学物质，以及单分散金属(金、银、铜、铂、钯)和氧化铁纳米粒子功能化与各种配体。产品被全球2000多组织采用，客户包括著名学术机构(哈佛大学、麻省理工学院、斯坦福、伯克利、牛津、ETH等)以及领先的高科技公司(Intel、Fuji、IBM、Qiagene等等)。
Superiorchemicalsforselfassembly,surfacemodificationandnanoparticles.
Acetyl-protectedthiols（乙酰保护硫醇）Calixarenes（杯芳烃）Couplingreagents（偶联试剂）Disulfides（二硫化物）Dithiolsfornanoparticleassembly（纳米颗粒组装用二硫醇）Fluorinatedthiolsandsilanes（氟化硫醇和硅烷）Functionalizedthiols（功能化硫醇）Graphenederivatives（石墨烯衍生物）Ligandsforironoxidesurfaces（氧化铁表面配体）MOFs（Metal-OrganicFrameworks，金属有机框架化合物）Photoswitchablethiols（光开关硫醇）Silanes（硅烷）ThiolatedCarbohydrates(mimickingglycans)（硫代碳水化合物-模拟聚糖）Thiolatedcrownethers（硫化冠醚）ThiolsanddisulfidesforfluorescentSAMs（用于荧光SAMs的硫醇和二硫化物）ThiolsforbioresistantandbiospecificSAMs（用于生物抗药性和生物特异性SAMs的硫醇）ThiolsforelectroactiveSAMs（用于电活性SAMs的硫醇）Thiophoshonates（硫代磷酸酯）Ultra-bioresistantZwitterionicligands（超生物电阻两性离子配体）Usefulsyntheticprecursorsandbuildingblocks（有用的合成前体和组成链段）
