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Overview:
IkBbeta is part of the NFkB complex and it inactivates NFkB complex by binding to it and trapping it in the cytoplasm. Phosphorylation of serine residues on IkBbeta mediated by IkB kinases leads to its destruction via the ubiquitination pathway thereby allowing activation of the NFkB complex which translocates into the nucleus and binds DNA at kappa-B-binding motifs (1). The PEST domain of IkBbeta can interact with two proteins KBRAS1 and KBRAS2 and this interaction can decrease the rate of degradation IkBbeta. IkBbeta has been shown to participate in multiple signaling pathways including adipocytokine signaling pathway, B-cell receptor signaling pathway, T-cell receptor signaling pathway and Hypoxia (2).
Gene Aliases:
IKBB, NFKBIB, TRIP9
Genbank Number:
NM_002503
References:
1. Fenwick, C. et al: A subclass of Ras proteins that regulate the degradation of I-kappa-B. Science 287: 869-873, 2000. 2. Hoffmann, A. et al: The I-kappa-B-NF-kappa-B signaling module: temporal control and selective gene activation. Science 298: 1241-1245, 2002.
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vectorlabs/Biotinylated Aleuria Aurantia Lectin (AAL)/B-1395/1 mg
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Mouse IgG)/PK-6102/1 kit
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