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Usbio/SNIP1, Recombinant, Human, aa258-396, His-Tag (Smad nuclear interacting protein 1)/100ug/S1014-96D188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Usbio/SNIP1, Recombinant, Human, aa258-396, His-Tag (Smad nuclear interacting protein 1)/100ug/S1014-96D

SNIP1 is smad nuclear interacting protein contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. This protein is an inhibitor of the TGF-beta signal transduction pathway and to be important in suppressing transcriptional activation dependent on the co-activators CBP and p300. Inhibition of NF-kappa B activity is a function of the N-terminal domain of SNIP1 and involves competition of SNIP1 and the NF-kappa B subunit, RelA/p65, for binding to p300, similar to the mechanism of inhibition of Smad signaling by SNIP1. Purified by using conventional chromatography techniques.||Source:|Recombinant human corresponding to aa258-396 of SNIP1, fused to His-tag at N-terminus, expressed in E.coli.||AA Sequence:|MGSSHHHHHH SSGLVPRGSH MRWRLYPFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVF QYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDT SEIDRKDDED EEEEEEVSDS||Molecular Weight: |~18.8kD (160aa) confirmed by MALDI-TOF||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.Source: E.coli|Purity: ~90% (SDS-PAGE)|Concentration: ~1mg/ml|Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8, 2mM DTT, 100mM sodium chloride, 20% glycerol.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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