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Stemcell/Human Recombinant Activin A, ACF/1000 \u00b5g/78132.2188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Stemcell/Human Recombinant Activin A, ACF/1000 \u00b5g/78132.2

Overview

Activin A is a member of the transforming growth factor beta (TGF-β) family of proteins produced by many cell types throughout development (Gurdon et al.). It is a disulfide-linked homodimer (two beta-A chains) that binds to heteromeric complexes of a type I (Act RI-A and Act RI-B) and a type II (Act RII-A and Act RII-B) serine-threonine kinase receptor (Attisano et al.). Activins primarily signal through SMAD2/3 proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, and metabolism (McDowell et al.). Activin A maintains the undifferentiated state of human embryonic stem cells (James et al.; Xiao et al.) and also facilitates differentiation of human embryonic stem cells into definitive endoderm (D’Amour et al.). This product is animal component-free.
Alternative Names:
Activin beta-A chain, EDF, Erythroid differentiation protein, FRP, FSH-releasing protein, INHBA, Inhibin betaA chain, Inhibin beta-1
Cell Type:
Endoderm, PSC-Derived; Mesoderm, PSC-Derived; Other; Pluripotent Stem Cells
Area of Interest:
Epithelial Cell Biology; Stem Cell Biology
Molecular Weight:
13.1 kDa monomer; 26.2 kDa dimer
Purity:
≥ 95%
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