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Stemcell/Anti-Mouse CD11b Antibody, Clone M1/70/100 u00b5g/60001PB.1188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Stemcell/Anti-Mouse CD11b Antibody, Clone M1/70/100 u00b5g/60001PB.1

Overview

The M1/70 antibody reacts with CD11b, an ~170 kDa type 1 transmembrane glycoprotein which associates non-covalently with CD18 to form the heterodimeric Mac-1 receptor. Through its interactions with ligands such as ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen, Mac-1 functions in several processes, including the adherence of neutrophils and monocytes to stimulated endothelium and phagocytosis of complement-coated particles. CD11b is expressed on the surface of granulocytes, monocytes, NK cells, dendritic cells, tissue macrophages, and subsets of T and B cells, and has been used as a marker to distinguish naïve and memory CD8+ T cells. CD11b is a relatively late marker for myeloid differentiation and is undetectable on most myelomonocytic hematopoietic progenitor cells and more primitive cells. The M1/70 antibody reportedly blocks iC3b binding to Mac-1. This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse Monocyte Isolation Kit (Catalog #19861).
Subtype:
Primary Antibodies
Target Antigen:
CD11b
Alternative Names:
alphaM integrin, C3biR, CR3, Ly-40, Mac-1, Mo1
Reactive Species:
Baboon; Rhesus; Chimpanzee; Human; Rabbit
Conjugation:
Biotin; FITC; PE; Unconjugated
Host Species:
Rat
Cell Type:
Granulocytes and Subsets; Monocytes
Application:
Cell Isolation; CyTOF; FACS; Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Radioimmunoassay; Western Blotting
Area of Interest:
Immunology
Clone:
M1/70
Gene ID:
16409
Isotype:
IgG2b, kappa
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