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Bpsbioscience/HSP90β, His-tag/50292/200 µg

Species:Human
HostSpecies:E.coli
MW:83kDa
Genbank#:AY359878
Tag(s):C-terminalHis-tag
a.a:fulllength
Background:
Hsp90(90kDaheatshockprotein)isamolecularchaperonethataidsproteinfoldingandqualitycontrolforalargenumberofclientproteins.FunctionalHsp90operatesasdimerandhasintrinsicATPaseactivity.TheHsp90dimeractsinconcertwithotherchaperones(e.g.Hsp70)andisregulatedbyanumberofco-chaperones/accessoryproteins(e.g.Hop,cdc37).Hsp90hasbeenshowntointeractwith>100proteinsandsomenotableclientsincludekinases(e.g.Raf-1),nuclearhormonereceptors(e.g.estrogenreceptors),transcriptionfactors(e.g.p53),GPCRs(e.g.CB2receptors)andionchannels(e.g.CFTR).Inhumans,theHsp90betaisoformisconstitutivelyexpressedwhereastheHsp90alphaisoformsisexpressedunderstressconditions.Hsp90playsanimportantroleinsometumorcelltypesbystABIlisingmutatedoncogenicproteins.InhibitionofHsp90betafunctionhasbeenshowntoplayaroleintumOrigenesisanddiseaseprogression.
Description:
HumanHeatShockProtein90β(GenBankAccessionNo.AY359878),fulllengthwithC-terminalHis-tag,MW=83kDa,expressedinanE.coliexpressionsystem.
UniProt
P08238
Synonym(s):
HSP90b,HeatShockProtein90b,HSP90beta,HSP90β
AssayConditions:
AssayedusingtheBPSHsp90βAssaykit,Cat.#50294.
Formulation:
40mMTris-HCl,pH8.0,110mMNaCl,2.2mMKCl,2mMDTT,and20%glycerol.
Format:
Aqueousbuffersolution
Storage/Stability:
Atleast6monthsat–80°C.Avoidfreeze/thawcycles.Proteinmaybedilutedto≥100µg/mlinPBS+glycerolandstoredat-80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.MilicevicZetal.,IntJOncol.2008Jun;32(6):1169-78.
2.ChaoC.C.etal.,JCellBiochem.2008Jul1;104(4):1286-96.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
HeatShockProteins
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
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