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Bpsbioscience/p38α, GST-tag/40070/10 µg

Species:Human
HostSpecies:Sf9insectcells
MW:67kDa
Genbank#:NM_139012
Tag(s):N-terminalGST-tag
a.a:fulllength
Background:
p38α(SAPK2A)isamemberofthep38MAPKfamilywhichareactivatedbyvariousenvironmentalstressesandproinflammatorycytokines(1).Theactivationofp38requiresitsphosphorylationbyMAPkinasekinases(MKKs),oritsautophosphorylationtriggeredbytheinteractionofMAP3K7IP1/TAB1proteinwiththiskinase(2).Thesubstratesofp38includetranscriptionregulatorATF2,MEF2C,MAX,cellcycleregulatorCDC25B,andtumorsuppressorp53,whichsuggesttherolesofthiskinaseinstressrelatedtranscriptionandcellcycleregulation,aswellasingenotoxicstressresponse.
Description:
Recombinantfull-lengthhumanp38alphawasexpressedbybaculovirusinSf9insectcellsusinganN-terminalGST-tag.ThegeneaccessionnumberisNM_139012.
Synonym(s):
CSBP1,CSBP2,CSPB1,PRKM14,PRKM15,SAPK2A,MAPK14
Purity:
≥90%
SpecificActivity:
77pmol/min/µg
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,10mMglutathione,0.1mMEDTA,0.25mMDTT,0.1mMPMSF,25%glycerol.
Format:
Aqueousbuffersolution
Storage/StABIlity:

>6monthsat-80°C

Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):

1.Han,J.etal.,Science265:808-811,1994.
2.Ge,B.etal.,Science295:1291-1294,2002.

Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Serine-Threonine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
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