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...trans-anethole on drug-metabolizing enzymes in the rat liver

ActionsCite Favorites Display options Display options Format Effects of the naturally occurring alkenylbenzenes eugenol and trans-anethole on drug-metabolizing enzymes in the rat liver 1 TNO Toxicology and Nutrition Institute, Department of Biological Toxicology, Zeist, The Netherlands. Effects of the naturally occurring alkenylbenzenes eugenol and trans-anethole on drug-metabolizing enzymes in the rat liver 1 TNO Toxicology and Nutrition Institute, Department of Biological Toxicology, Zeist, The Netherlands. In order to study the effects of trans-anethole and eugenol on drug-metabolizing enzyme activities in vivo, male Wistar rats were treated by gavage with trans-anethole (125 or 250 mg/kg body weight) or eugenol (250, 500 or 1000 mg/kg body weight) daily for 10 days. In liver microsomes and cytosol various phase-I and phase-II biotransformation enzyme activities were determined. No effect on total cytochrome P-450 content in liver microsomes from rats treated with eugenol or trans-anethole was observed. Administration of 1000 mg eugenol/kg body weight, but not the lower doses, significantly increased cytochrome P-450-dependent 7-ethoxy-resorufin O-deethylation (EROD) and 7-pentoxyresorufin O-depentylation (PROD); administration of trans-anethole (125 or 250 mg/kg body weight) did not alter EROD and PROD activities. In rat liver cytosol, UDP-glucuronyl transferase (GT) activity towards the substrate 4-chlorophenol was significantly increased in all treated rats, and activity towards 4-hydroxybiphenyl as substrate was significantly increased in rats treated with 250 mg trans-anethole/kg or with 500 or 1000 mg eugenol/kg. DT-diaphorase (DTD) activity was only significantly enhanced in the liver cytosol of rats treated with trans-anethole at 250 mg/kg body weight. Enhancement of cytosolic glutathione S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene was found for all eugenol- and trans-anethole-treated rats. In addition, significantly increased levels of GST subunit 2 were measured by HPLC in the liver cytosol of rats treated with eugenol (500 or 1000 mg/kg body eight) or trans-anethole (250 mg/kg body weight). It is concluded that both eugenol and trans-anethole preferentially induced phase II biotransformation enzymes in rat liver in vivo. Abraham SK. Food Chem Toxicol. 2001 May;39(5):493-8. doi: 10.1016/s0278-6915(00)00156-3. Food Chem Toxicol. 2001. PMID: 11313116 Oetari S, et al. Biochem Pharmacol. 1996 Jan 12;51(1):39-45. doi: 10.1016/0006-2952(95)02113-2. Biochem Pharmacol. 1996. PMID: 8534266 Heiskanen K, Linström-Seppä P, Haataja L, Vaittinen SL, Vartiainen T, Komulainen H. Heiskanen K, et al. Toxicology. 1995 Jun 26;100(1-3):121-8. doi: 10.1016/0300-483x(95)03075-q. Toxicology. 1995. PMID: 7624869 Yokota H, et al. Biochem Pharmacol. 1988 Mar 1;37(5):799-802. doi: 10.1016/0006-2952(88)90164-5. Biochem Pharmacol. 1988. PMID: 3125837 Can J Biochem Cell Biol. 1984 Jun;62(6):486-94. doi: 10.1139/o84-066. Can J Biochem Cell Biol. 1984. PMID: 6380687 Costa A, et al. Am J Clin Dermatol. 2016 Aug;17(4):369-85. doi: 10.1007/s40257-016-0193-5. Am J Clin Dermatol. 2016. PMID: 27164914 Free PMC article. Review. Sadati SN, Ardekani MR, Ebadi N, Yakhchali M, Dana AR, Masoomi F, Khanavi M, Ramezany F. Sadati SN, et al. Pharmacogn Rev. 2016 Jan-Jun;10(19):33-8. doi: 10.4103/0973-7847.176546. Pharmacogn Rev. 2016. PMID: 27041871 Free PMC article. Review. Porto Mde P, da Silva GN, Luperini BC, Bachiega TF, de Castro Marcondes JP, Sforcin JM, Salvadori DM. Porto Mde P, et al. Mol Biol Rep. 2014 Nov;41(11):7043-51. doi: 10.1007/s11033-014-3657-9. Mol Biol Rep. 2014. PMID: 25103019

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