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Accelagen/PAK3KD (recombinant human PAK3 kinase domain)/K0106B/ Bulk

Description:
HumanPAK3kinase(UniProt:O75914;NCBI:NM_001128166)belongstoafamilyofp21-activatedkinases.Theseserine/threoninekinasesserveastargetsforthesmallGTPbindingproteinsCdc42andRacandhavebeenimplicatedinawiderangeofBIOLOGicalactivities.OverexpressionofPAK3hasbeendetectedincertaintypesofcancer.MutationsofPAK3havebeenassociatedwithlearningdisABIlityandX-linkedmentalretardation.PAK3KDisarecombinantwildtypehumanPAK3kinasedomain(aminoacids246-544offull-lengthhumanPAK3)expressedinE.coliandpurifiedtonearhomogeneity.

MolecularMassandPhosphorylation:
Thecalculatedmassis33,758.PAK3KDisphosphorylatedonT421andpartiallyphosphorylatedatadditionalsiteswithmassmeasuredat33,835(1P),33,915(2P),33,995(3P).

StabilityandStorage:
Stableat-70oCfor12monthsfromdateofreceipt.Proteinshouldbethawedonice.Proteincanbeflash-frozeninliquidnitrogenandstoredat-70oC.

Applications:
Enzymaticstudies,inhibitorscreen,andselectivityprofiling
Highconcentrationavailableforcrystallization

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