Description: HumanPAK6kinase(UniProt:Q9NQU5;NCBI:NM_020168)belongstoafamilyofp21-activatedkinases.Theseserine/threoninekinasesareregulatedbythesmallGTPbindingproteinsCdc42andRacandhavebeenimplicatedinawiderangeofBIOLOGicalactivities.PAK6wasfoundtointeractwithandrogenreceptor.PAK6KDisarecombinantwildtypehumanPAK6kinasedomain(aminoacids385–680offull-lengthhumanPAK6)expressedinE.coliandpurifiedtohomogeneitywithfullactivity. MolecularMassandPhosphorylation: Thecalculatedmassis34,161.PAK6KDisfullyphosphorylatedatS560withameasuredmassof34,242(1P). StABIlityandStorage: Stableat-70oCfor12monthsfromdateofreceipt.Proteinshouldbethawedonice.Proteincanbeflash-frozeninliquidnitrogenandstoredat-70oC. Applications: Enzymaticstudies,inhibitorscreen,andselectivityprofiling Highconcentrationavailableforcrystallization |
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