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Alomone/Anti-β2-Adrenergic Receptor (extracellular) Antibody/AAR-016/0.2 ml

Cat#:AAR-016
  • LyophilizedPowder
  • AntigenIncl.
  • ShippedatRoomTemp.
    • Type:Polyclonal
    Source:Rabbit
    Reactivity:m,r
    Mayalsoworkin:h
    Immunogen
    Peptide(C)NGSRAPDHDVTQERDE,correspondingtoaminoacidresidues15-30ofmouseADRB2 (AccessionP18762).Extracellular,N-terminus.
    Accession(Uniprot)NumberP18762
    GeneID11555
    PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.
    HomologyHuman-15/16aminoacidresiduesidentical;rat-14/16aminoacidresiduesidentical.
    PurityAffinitypurifiedonimmobilizedantigen.
    FormulationLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN3.
    StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.
    Reconstitution25µl,50μlor0.2mldoubledistilledwater(DDW),dependingonthesamplesize.
    Antibodyconcentrationafterreconstitution0.7mg/ml.
    StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°Cforupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000xg5min).
    ControlantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.
    Controlantigenreconstitution100µldoubledistilledwater(DDW).
    Controlantigenstorageafterreconstitution-20°C.
    PreadsorptionControl1μgpeptideper1μgantibody.
    StandardqualitycontrolofeachlotWesternblotanalysis.
    Applications:ih,wb
    Mayalsoworkin:ic,ifc,ip,lci
    Westernblot
    Westernblotanalysisofratheart(lanes1and3)andlung(lanes2and4)lysates:
    1,3.Anti-β2-AdrenergicReceptor(extracellular) Antibody(#AAR-016),(1:200).
    2,4.Anti-β2-AdrenergicReceptor(extracellular)Antibody,preincubatedwiththecontrolpeptideantigen.
    Immunohistochemistry
    Expressionof β2-Adrenoceptorinratlung
    Immunohistochemicalstainingofparaffin-embeddedsectionofratlungusingAnti-β2-AdrenergicReceptor(extracellular) Antibody(#AAR-016),(1:100).β2-Adrenoceptorisexpressedintherespiratoryepithelium.Hematoxilinisusedasthecounterstain.
    References
    1. IUPHARRECEPTORDATABASE|ADRENOCEPTORS
    2. Piascik,M.T.andPerez,D.M.(2001)J.Pharmacol.Exp.Ther.298,403.
    3. Pullar,C.E.etal.(2006)FASEBJ.20,76.
    4. Oostendorp,J.etal(2005)Am.J.Respir.Crit.CareMed.172,322.
    5. Giembycz,M.A.andNewton,R.(2006)Eur.Respir.J.27,1286.
    Scientificbackground

    Adrenergicreceptors(alsocalledadrenoceptors)arethereceptorsforthecatecholaminesadrenalineandnoradrenaline(calledepinephrineandnorepinephrineintheUnitedStates).Adrenalineandnoradrenalineplayimportantrolesinthecontrolofbloodpressure,myocardialcontractilerateandforce,airwayreactivity,andavarietyofmetabolicandcentralnervoussystemfunctions.
     
    AdrenergicreceptorsaremembersoftheG-proteincoupledreceptor(GPCR)superfamilyofmembraneproteins.Theyshareacommonstructureofsevenputativetransmembranedomains,anextracellularaminoterminus,andacytoplasmiccarboxylterminus.

    Adrenoceptorsaredividedintothreetypes:α1,α2 andβ-adrenoceptors.Eachtypeisfurtherdividedintoatleastthreesubtypes:α1A,α1B,α1D,α2A,α2B,α2C,β1,β2,β3.1,2 Adrenoceptors areexpressedinnearlyallperipheraltissuesandinthecentralnervoussystem.1,2
     
    β2-Adrenoceptorsaremainlypostsynapticreceptors.Theyareexpressedonanumberoftissuesincludingbloodvessels,bronchi,gastrointestinaltract(GIT),skeletalmuscle,liverandmastcell.3 Functionalβ2-adrenoceptorswerealsofoundonlymphocytes,macrophagesandneutrophils.4,5 Theyarealsotheonlyβ-adrenoceptorsubtypeexpressedinkeratinocytes,fibroblastsandmelanocytes.3 Activationofβ2-adrenoceptorsresultsinvasodilation,relaxationoftheGIT,inhibitionofhistaminereleasefrommastcellsandbronchodilation.SelectiveagoNISTsofβ2-adrenoceptorsareusedtotreatasthmaandotherrelatedbronchospasticconditionssuchasChronicobstructivepulmonarydisease(COPD).5 

    Applicationkey:

    CBE-Cell-basedELISA,FC-Flowcytometry,ICC-Immunocytochemistry,IE-IndirectELISA,IFC-Indirectflowcytometry,IHC-Immunohistochemistry,IP-Immunoprecipitation,LCI-Livecellimaging,N-Neutralization,WB-Westernblot

    Speciesreactivitykey:

    H-Human,M-Mouse,R-Rat
    LyophilizedPowderControlAntigenIncluded
    receivea25µlfreetrialsample!
    Lastupdate:01/01/2019

    Anti-β2-AdrenergicReceptor(extracellular)Antibody(#AAR-016)isahighlyspecificantibodydirectedagainstanextracellularepitopeofthemouseβ2-adrenoceptor.Theantibodycanbeusedinwesternblotandimmunohistochemistryapplications.Ithasbeendesignedtorecognizeβ2ARfrommouse,rat,andhumansamples.

    Forresearchpurposesonly,notforhumanuse
    Westernblot
    Westernblotanalysisofratheart(lanes1and3)andlung(lanes2and4)lysates:
    1,3.Anti-β2-AdrenergicReceptor(extracellular) Antibody(#AAR-016),(1:200).
    2,4.Anti-β2-AdrenergicReceptor(extracellular)Antibody,preincubatedwiththecontrolpeptideantigen.
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