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Biosensis/Rabbit polyclonal to CD44 (aa728-742) / Phagocytic glycoprotein 1 / PGP-1: affinity purified IgG/R-1721-100/100 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Biosensis/Rabbit polyclonal to CD44 (aa728-742) / Phagocytic glycoprotein 1 / PGP-1: affinity purified IgG/R-1721-100/100 µg

DescriptionTheproteinidentifiedasCD44isalsoknownasthereceptorforhyaluronicacid(HA).Theproteinmediatescell-cellandcell-matrixinteractionsthroughitsaffinityforHA,andpossIBLyalsothroughitsaffinityforotherligandssuchasosteopontin,collagens,andmatrixmetalloproteinases(MMPs).AdhesionwithHAplaysanimportantroleincellmigration,tumorgrowthandprogression.Incancercells,CD44mayplayanimportantroleininvadopodiaformation,anditalsoisinvolvedinlymphocyteactivation,recirculationandhoming,andinhematopoiesis.AlteredexpressionordysfunctionofCD44causesnumerouspathogenicphenotypes.CD44hasgreatproteinheterogeneityduetonumerousalternativesplicingandpost-translationalmodificationevents.Biosensis"anti-CD44rabbitpolyclonalantibodyisanewantibodymadeagainstasyntheticpeptideepitopeneartheveryC-terminus,cytoplasmicdomainofhumanCD44.Theantibodyhasbeenshowntoreactwithmultiplespeciesincludinghuman,mouseandrat,inbothwesternblotandimmunohistochemistryapplicationsincludingformalinfixed,paraffinembeddedtissues.Seeapplicationsdetailforspecificuseinstructions.
BatchNo.seeviallabel
Unitsize100µg
AntigenAsyntheticpeptidecorrespondingtoasequenceattheC-terminusofhumanCD44cytoplasmicdomainaa728-742.Theimmunogendiffersbyonlysingleaminoacidbetweenhuman,mouseandratproteins.
SequenceDETRNLQNVDMKIGV
AntigenLocationcytoplasmic,C-terminus
AntigenLength15aa
AntibodyTypepolyclonal
IsotypeIgG
OtherNamesCDw44,Epican,ExtracellularmatrixreceptorIII,ECMR-III,GP90lymphocytehoming/adhesionreceptor,HUTCH-I,Heparansulfateproteoglycan,Hermesantigen,Hyaluronatereceptor,Phagocyticglycoprotein1,PGP-1,PhagocyticglycoproteinI,PGP-I,CD_antigen:CD44
AccessionP16070
ProducedinRabbit
MolecularWeightVariabledependinguponsplicing,80-to250-kDa
PurityAffinitypurifiedoverpeptide
ApplicationsWB:Westernblot:reducedRIPAsamplesormembranepreparations(0.1-.5ug/mL)dependentuponantigenloadandantibodyincubationtimesanddetectionsubstrateused.

IH:frozenoracetonefixedtissue:0.5-1.0ug.mL,permeABIlizationisnecessaryasepitopeisinternal
IH(P):1-2ug/mLwithHEIRtreatmentrequired.
Formlyophilized.
AppearanceEachvialcontains100ugpurifiedantibody,and5mgBSA,0.9mgNaCl,0.2mgNa2HPO4,0.05mgThimerosal,0.05mgNaN3.
Reconstitution0.2mlofdistilledwaterwillyieldaconcentrationof500μg/ml.
StorageAt-20˚Cforoneyear.Afterreconstitution,at4˚Cforonemonth.Itcanalsobedividedintoaliquotsandstoredfrozenat-80˚Cforalongertime.Avoidrepeatedfreezingandthawing.
ExpiryDate12monthsafterpurchase.
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