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A-2"-MOE-Phosphoramidite
| Catalogue No. | Description | Pack Size | Price | Qty |
|
|---|---|---|---|---|---|
| 10-3200-05 | A-2"-MOE-Phosphoramidite | 0.5g | £30.00£28.50Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 10-3200-20 | A-2"-MOE-Phosphoramidite | 2.0g | £120.00£114.00Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 10-3200-SP | A-2"-MOE-Phosphoramidite | 1.0g | £60.00£57.00Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
A-2"-MOE-Phosphoramidite
Like the very similar 2’-OMe backbone, the 2’-O-methoxyethyl-RNA (2’-MOE) backbone provides enhanced duplex stability, significant nuclease resistance and relatively low toxicity. As a result, 2’-MOE has been an attr
active backbone for many therapeutic candidates, several of which have been approved by the FDA. These drugs have included 1) 2’-MOE/DNA chimeras to facilitate RNase H cleavage of target RNA sequences as well as 2) steric blocking oligonucleotides to alter the splicing of mRNA. The standard 2’-MOE nucleotides are A, 5-Me-C, G and 5-Me-U.
5"-O-(4,4"-Dimethoxytrityl)-2"-O-methoxyethyl-N6-benzoyl-adenosine -3"-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
Product Specifications
| Specifications | |
|---|---|
| Diluent | Anhydrous Acetonitrile |
| Storage | Refrigerated storage, maximum of 2-8°C, dry |
| Stability | 1-2 Days |
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