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Athens Research & Technology/GC-Globulin, Human Plasma, Mixed Type (Vitamin D Binding Protein)/16-16-070307/1 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Athens Research & Technology/GC-Globulin, Human Plasma, Mixed Type (Vitamin D Binding Protein)/16-16-070307/1 mg

MW:56,000
ExtinctionCoefficient:0.63

Lyophilizedfrom20mMNaphosphate,pH7.4,with150mMNaCl.

Storage:-20°C

BuyPurifiedNativeHumanGCGlobulin/VitaminDBindingProtein
Price$60.00/mg.BulkQtyAvailable.

Analpha2glycoproteincomposedofasinglepolypeptidechainandpresentinplasmaatlevelsof20-55mg/100ml.ItfunctionsinthebindingandtransportofvitaminDandmayalsoplayanimportantroleinactinhomeostatissinceithasbeenshowntobindmonomericactinwithhighaffinity.GC-globulinalsobindsmembranesofbothcirculatingBandTlymphocytes.Clinically,concentrationsarereducedinpatientswithsevereliverdiseases.GC-globulinmayalsoplayanimportantroleinthemechanismoftheosteomalaciathatoccurswithItai-Itaidisease.

Ref:
Lee,W.M.etal.1987.Hepatology,7,825.
Teranishi,H.etal.1983.Toxicol.Lett.15,7.

Purity:>=95%bySDS-PAGE

ProductCitation:
Trujillo,Glenda,DavidM.HABIel,LingyinGe,MahalakshmiRamadass,NancyE.Cooke,andRichardR.Kew."NeutrophilRecruitmenttotheLunginBothC5a-andCXCL1-InducedAlveolitisIsImpairedinVitaminD–BindingProtein-DeficientMice." TheJournalofImmunology (2013).
Ge,Lingyin,GlendaTrujillo,EdmundJ.Miller,andRichardR.Kew."CirculatingComplexesoftheVitaminDBindingProteinwithG-ActinInduceLungInflammationbyTargetingEndothelialCells." ImmunoBIOLOGy (2013).

PreparedfromplasmashowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests.

AthensResearch&TechnologyproductsarelaboratoryreagentsandarenottobeadmiNISTeredtohumansorusedforanydrugpurpose.Forresearchuseonly.

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