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MW:57,000
ExtinctionCoefficient:1.97
Lyophilizedfrom11.9mMphosphate,137mMNaCl,2.7mMKCl,pH7.4.
Storage:-20°C
BuyPurifiedNativeHumanHemopexin,HumanPlasma.
Price$185.00/mg.BulkQtyAvailable.
Hemopexinisasingle-chainproteinbelongingtothefamilyofbloodtransportproteins.Itbindstohemereleasedintothebloodstreamduringthedegradationprocess.Recentstudieshavedemonstratedthathemopexinactsasanextracellularantioxidantagainsthemoglobin-mediateddamageininflammation.Hemopexinprotectsagainsthemetoxicityandconservesandrecyclesiron.Abnormallevelsofhemopexinareassociatedwithhemolyticanemia,chronicneuromusculardisease,andacuteintermittentporphyria.
Purity:>=95%bySDS-PAGE.
Ref:Strop,P.,etal.1981.J.Chromat.214,317;Miller,Y.I.,etal.1996.Biochem.35,13112.
ProductCitation:
Chen,Grace,etal."Heme-inducedneutrophilextracellulartrapscontributetothepathogenesisofsicklecelldisease." Blood (2014):blood-2013.
Lipiski,Miriam,etal."HumanHp1-1andHp2-2phenotype-specifichaptoglobintherapeuticsarebotheffectiveinvitroandinguineapigstoattenuatehemoglobintoxicity." Antioxidants&redoxsignaling 19,no.14(2013):1619-1633.
Zager,RichardA.,AliCMJohnson,andKirstenBecker."Renalcorticalhemopexinaccumulationinresponsetoacutekidneyinjury." AmericanJournalofPhysiology-RenalPhysiology 303,no.10(2012):F1460-F1472.
PreparedfromplasmashowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests.
AthensResearch&TechnologyproductsarelaboratoryreagentsandarenottobeadmiNISTeredtohumansorusedforanydrugpurpose.Forresearchuseonly.
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