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Everest Biotech/Recombinant E.coli MAP 500μg/3703335001/500μg

Methionineaminopeptidase1,METAP,alsonamedMAP1,MetAP1,PeptidaseM1,isamemberoftheM24familyofmetalloproteases.METAPsplayacentralroleforproteinmaturationastheyremovetheinitiatorMetresiduefromnewlysynthesizedproteinsandareessentialforcellgrowth.ThreeMETAPgenes(METAP1,METAP2andMAP1D)havebeenidentifiedinthehumangenome.METAP1andMETAP2havedifferentsubstratespecificityduetothedifferencesinbothsizeandshapeoftheactivesites.METAP1playsanimportantroleinG(2)/Mphaseregulationofthecellcycleandmayserveasapromisingtargetforthediscoveryanddevelopmentofnewanticanceragents.Fumagillin,anaturalcompound,covalentlymodifiesanactiveHisresidueofMETAP2andpreventsthevascularizationandmetasisoftumors.

SourceE.coli
NamesMethionineAminopeptidase,MAP,PeptidaseM,map
Accession#P0AE18
FormulationSuppliedasa0.2μMfilteredsolutionof20mMTris-HCl,100mMNaCl,50%Glycerol,pH8.0
ShippingTheproductisshippedondryice/icepacks.
StorageStoreat<-20°C,stablefor6monthsafterreceipt.
Pleaseminimizefreeze-thawcycles.
PurityGreaterthan95%asdeterminedbySEC-HPLCandreducingSDS-PAGE.
EndotoxinLessthan0.1ng/μg(1IEU/μg).
AminoAcidSequence
MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDELEHHHHHH
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