Nanocs/SPDP (Succinimidyl 3[2pyridyldithio] propionate)/SPD01/2x10 mg

SPDPCrosslinkerDescription:

NanocsSnapLink^TMSPDPcrosslinker,N-Succinimidyl3-(2-pyridyldithio)propionicacid,alsocalledN-succinimidyl3-(2-pyridyldithio)-propionate,orOPSS-NHS,isashort-lengthcrosslinkerforaminetosulfhydryl(thiol)conjugationviaitsNHS-esterandpyridyldithiolreactivegroupsthatformcleavabledisulfidebondswithfreethiolgroups.NanocsLC-SPDPisalong-lengthcrosslikerforaminetosulfhydrylconjugationviaitsNHS-esterandpyridyldithiolreactivegroupsthatformcleavabledisulfidebondswithfreethiolgroups.

InadditiontoabovehydrophobicSPDPcrosslinker,Nanocsalsoofferwater-solubleSPDPcrosslinkereitherwithsulfonatedNHS(Sulfo-SPDP)orPegylatedSPDPcrosslinker,suchasourPEGOPSSproducts.TheseSPDPcrosslinkersareheterobifunctionalandthiolcleavablecrosslinkers.

SPDPCrosslinkerPhysicalProperties:

• Appearance:Off-white/whitesolid;
• Reactivegroups:NHSesterandpyridyldithiol;
• Reactivetowards:amino(amine)andsulfhydryl(thiol)groups;
• SPDPcrosslinkerismembranepermeable;
• Solubility:SolubleinDMForDMSO;

SPDPApplications:

• Addingthiol/sulfhydrylgroupstoproteins,antibodiesorothermoleculesbyreactingwithaminegroups;
• Reversiblecrosslinkingofproteinsorothermolecules;

SPDPStorageConditions:

• Storeat-20⁰C,desicate.Avoidfrequentthawandfreeze.