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Hello Bio/NS 1619/HB1048/25mg

Productoverview

  • Name
    NS1619
  • Shortdescription
    Potent,selectiveKCa1.1channelactivator
  • BIOLOGicaldescription
    PotentandselectiveKCa1.1channelactivator(EC50=3.6µM).SelectivelyincreasesthebloodbrainbarrierpermeABIlity.Displaysvasorelaxantproperties
  • Biologicalaction
    Activator
  • Purity
    >98%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
  • MolecularWeight
    362.23
  • Chemicalstructure
    NS 1619 [153587-01-0]
  • MolecularFormula
    C15H8F6N2O2
  • CASNumber
    153587-01-0

StoringandUsingYourProduct

  • Storageinstructions
    +4°C
  • Solubilityoverview
    solubleinDMSO(100mM)orethanol(100mM)
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforNS1619

  • Large-conductanceK+channelopenersNS1619andNS004asinhibitorsofmitochondrialfunctioningliomacells.

    DebskaGetal(2003)BiochemPharmacol65(11):1827-34.
    PubMedID:12781334

  • RoleofROS/RhoA/PI3K/PKBsignalinginNS1619-mediatedblood-tumorbarrierpermeabilityincrease.

    GuYTetal(2012)JMolNeurosci48(1):302-12.
    PubMedID:22581438

  • 5-(4"-Substituted-2"-nitroanilino)-1,2,3-triazolesasnewpotentialpotassiumchannelactivators.I.

    BiagiGetal(2000)EurJMedChem35(7-8):715-20.
    PubMedID:10960187

  • LargeconductanceCa2+-activatedK+channelactivationwithNS1619decreasesmyogenicandneurogeniccontractionsofratdetrusorsmoothmuscle.

    SoderRPetal(2011)EurJPharmacol670(1):252-9.
    PubMedID:21914438
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