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Hello Bio/Perlapine hydrochloride (water soluble)/HB6126/10mg

Productoverview

  • Name
    Perlapinehydrochloride(watersoluble)
  • Shortdescription
    Novel,potentandselectivehM3DqDREADDreceptoragoNIST.Watersoluble.
  • BIOLOGicaldescription

    Perlapinehydrochlorideisawatersolubleversionofperlapinewhichisanovel,potentandselective,non-CNO(ClozapineNOxide)hM3DqDREADDreceptoragonist(EC50=2.8nM).PerlapinealsoactivatestheinhibitoryhM2DiandhM4DiGi-DREADDs.


    Perlapineshows>10,000-foldselectivityforhM3DqoverhM3muscarinicreceptor.

    Unlike CNO,perlapineisespeciallysuitedfortranslationalstudies.Perlapinealsoactsasasleepinducing,hypnoticagent.


    ClozapineN-oxide(CNO) (watersoluble),Compound21,SalvinorinB(SalB)andperlapinefreebase arealsoavailable.

  • Alternativenames
    NSC291840hydrochloride
  • Biologicalaction
    Activator
  • Purity
    >98%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepinedihydrochloride
  • MolecularWeight
    360.3
  • Chemicalstructure
    Perlapine hydrochloride
  • MolecularFormula
    C19H21N3.2HCl
  • SMILES
    CN1CCN(CC1)C2=NC3=CC=CC=C3CC4=CC=CC=C42.Cl.Cl
  • Source
    Synthetic
  • Appearance
    Whitesolid

StoringandUsingYourProduct

  • Storageinstructions
    Roomtemperature
  • Solubilityoverview
    Solubleinwater(100mM)
  • Handling
    Hydroscopicsolid,contactwithairmaycausematerialtobecomesticky.Productperformanceshouldnotbeaffectedbutwerecommendstoringthematerialinasealedjar.
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse

ReferencesforPerlapinehydrochloride(watersoluble)

  • Thefirststructure-activityrelationshipstudiesfordesignerreceptorsexclusivelyactivatedbydesignerdrugs.

    Chenetal(2015)ACSChemNeurosci6(3):476-84
    PubMedID:25587888

  • 6-(4-Methyl-1-piperazinyl)morphanthridine(Perlapine),anewtricycliccompoundwithsedativeandsleep-promotingproperties.Apharmacologicalstudy.

    Stilleetal(1973)Psychopharmacologia24(4):325-37
    PubMedID:4695567

  • DREADDsforNeuroscientists.

    RothBl(2016)Neuron89(4):683-94
    PubMedID:26889809
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