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Hello Bio/MCC950 sodium salt/HB4636/5mg

Productoverview

  • Name
    MCC950sodiumsalt
  • Shortdescription
    Potent,selectiveNLRP3inflammasomeinhibitor
  • BIOLOGicaldescription
    Potent,selectiveandorallyavailableNLRP3inflammasomeinhibitor.BlocksthereleaseofIL-1betainmacrophagesprimedwithLPSandactivatedwithATPornigericin,butitdoesnotinhibitNLRP1,NLRC4,AIM2,TLR2signalingorprimingofNLRP3.PreventsoligomerizationofASCincellsstimulatedwithLPSandnigericin.Activeinvivo,blockingtheproductionofIL-1betaandenhancingsurvivalinmousemodelsofmultiplesclerosisandcryopyrin-associatedperiodicsyndrome(CAPS).AlsoactiveinexvivosamplesfromindividualswithMuckle-Wellssyndrome.PotentialtherapeuticagentforNLRP3-associatedsyndromes,includingautoinflammatoryandautoimmunediseases.
  • Purity
    >98%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    1-(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea
  • MolecularWeight
    426.5
  • CASNumber
    256373-96-3
  • InChiKey
    SNIGCXULUAXYGW-UHFFFAOYSA-N
  • Appearance
    Crystallinesolid

StoringandUsingYourProduct

  • Storageinstructions
    +4°C
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
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