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Hello Bio/Ophiobolin A/HB0474/1mg

Productoverview

  • Name
    OphiobolinA
  • Shortdescription
    IrreversIBLecalmodulinantagoNIST
  • BIOLOGicaldescription
    Irreversiblecalmodulinantagonistthatreactswithlysineresidues(IC500.87-3.7µM).Alsoinhibitscalcium-dependenthumangrowthhormone(hGH)release(approxKi=10µM).Amembranepermeablefungalmetaboliteandaphytotoxin.Displaysantitumorandapoptoticinducingproperties.
  • Biologicalaction
    Antagonist
  • Purity
    >95%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    CochliobolinA
  • MolecularWeight
    400.6
  • Chemicalstructure
    Ophiobolin A [988837]
  • MolecularFormula
    C25H36O4
  • CASNumber
    4611-05-6
  • PubChemidentifier
    5281387
  • SMILES
    C[C@H]1C[C@@H](O[C@@]12CC[C@]3([C@H]2C/C=C([C@@H]4[C@H](C3)[C@](CC4=O)(C)O)/C=O)C)C=C(C)C

StoringandUsingYourProduct

  • Solubilityoverview
    solubleinDMSOorDMF
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforOphiobolinA

  • OphiobolinA,asesterterpenoidfungalphytotoxin,displayshigherinvitrogrowth-inhibitoryeffectsinmammalianthaninplantcellsanddisplaysinvivoantitumoractivity.

    BuryMetal(2013)IntJOncol43(2):575-85.
    PubMedID:23754298

  • IdentificationofthebindingandinhibitionsitesinthecalmodulinmoleculeforophiobolinAbysite-directedmutagenesis.

    KongAuTetal(1998)PlantPhysiol118(3):965-73.
    PubMedID:9808741

  • Calmodulinandlipidbindingtosynaptobrevinregulatescalcium-dependentexocytosis.

    QuetglasSetal(2002)EMBOJ21(15):3970-9.
    PubMedID:12145198
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