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Hello Bio/SKF 89976A hydrochloride/HB0976/10mg

Productoverview

  • Name
    SKF89976Ahydrochloride
  • Shortdescription
    Potent,selective,competitiveGAT-1GABAuptakeinhibitor
  • BIOLOGicaldescription
    Potent,selectiveandcompetitiveGAT-1GABAuptakeinhibitor.SelectiveforGAT-1overGAT-2,GAT-3andBGT-1(IC50valuesare0.13,550,944and7210µMrespectively).InhibitsGABAuptake(Ki=7µM)andtransmitter-gatedcurrents(Ki=0.03µM).Showsanticonvulsantactions.Blood-brainbarrierpermeable.
  • Biologicalaction
    Inhibitor
  • Purity
    >99%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylicacidhydrochloride
  • MolecularWeight
    371.91
  • Chemicalstructure
    SKF 89976A hydrochloride [85375-15-1]
  • MolecularFormula
    C22H25NO2.HCl
  • CASNumber
    85375-15-1

StoringandUsingYourProduct

  • Storageinstructions
    +4°C(desiccate)
  • Solubilityoverview
    solubleinwater(100mM,gentlewarming)orDMSO(100mM)
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforSKF89976Ahydrochloride

  • IdentificationandselectiveinhibitionofthechannelmodeoftheneuronalGABAtransporter1.

    KrauseSetal(2005)MolPharmacol68(6):1728-35.
    PubMedID:16150932

  • Orallyactiveandpotentinhibitorsofgamma-aminobutyricaciduptake.

    AliFEetal(1985)JMedChem28(5):653-60.
    PubMedID:2985785

  • ComparisonoftheanticonvulsanteffectsoftwonovelGABAuptakeinhibitorsanddiazepaminamygdaloidkindledrats.

    SchwarkWSetal(1985)NaunynSchmiedebergsArchPharmacol329(4):367-71.
    PubMedID:4033806
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