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Hello Bio/Valproic acid sodium salt/HB0867/10g

Productoverview

  • Name
    Valproicacidsodiumsalt
  • Shortdescription
    Histonedeacetylaseinhibitor.ShowsmultitudeofBIOLOGicalactions.Enablespluripotentstemcellinductionfromsomaticcells.
  • Biologicaldescription
    Histonedeacetylaseinhibitor(IC50=400µMatHDAC1).Showsmultitudeofbiologicalactions.Canbeusedtoproducepluripotentstemcells(iPScells)withonlyOct4andSox2factorsrequiredinaddition.ActivatesWnt-dependentgeneexpressionandshowsanti-inflammatory,anti-canceranti-epilepticandneuroprotectiveactions.Blood-brainbarrierpermeable.
  • Alternativenames
    VPA
  • Biologicalaction
    Inhibitor
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    Sodium2-propylpentanoate
  • MolecularWeight
    166.19
  • Chemicalstructure
    Valproic acid sodium salt [1069-66-5]
  • MolecularFormula
    C8H15NaO2
  • CASNumber
    1069-66-5

StoringandUsingYourProduct

  • Storageinstructions
    roomtemperature(desiccate)
  • Solubilityoverview
    solubleinwater(100mM)orDMSO(50mM)
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforValproicacidsodiumsalt

  • Histonedeacetylaseisadirecttargetofvalproicacid,apotentanticonvulsant,moodstABIlizer,andteratogen.

    PhielCJetal(2001)JBiolChem276(39):36734-41.
    PubMedID:11473107

  • ValproicacidinhibitsAbetaproduction,neuriticplaqueformation,andbehavioraldeficitsinAlzheimer"sdiseasemousemodels.

    QingHetal(2008)JExpMed205(12):2781-9.
    PubMedID:18955571

  • Potentiationofanticancereffectofvalproicacid,anantiepilepticagentwithhistonedeacetylaseinhibitoryactivity,bythecyclin-dependentkinaseinhibitorP276-00inhumannon-small-celllungcancercelllines.

    ShirsathNetal(2013)LungCancer82(2):214-21.
    PubMedID:24051085

  • InductionofpluripotentstemcellsfromprimaryhumanfibroblastswithonlyOct4andSox2.

    HuangfuDetal(2008)NatBiotechnol26(11):1269-75.
    PubMedID:18849973
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