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LifeSensors/AC1002 3-Methyladenine 100mg/AC1002 3-Methyladenine 100mg

Background

InhibitsautophagybyblockingautophagosomeformationviainhibitionoftypeIIIphosphatidylinositol3-kinases(PI-3K)1,2.Protects1321N1astrocytomacellsagainstpyocyaninandhydroxyphenazine-inducedtoxicity3.Inhibitionofautophagyby3-MAleadstoenhancedapoptosisinducedbyavarietyofagentsincludingcelastrol4,cisplatin5andsorafenib6inseveraldifferentcelllines.Cellpermeable.


Application

Autophagosomeinhibitor



ProductInformation

Purity:           >98%byTLC

MW:                149.2

Formula:           C6H7N5

CASNo.            5142-23-4

PhysicalState:   Lyophilizedwhitepowder

Amount:           25mg,50mg,100mg

Solubility:           3mg/mlinDMSO;10mg/mLinwarmDMF;5mg/mLinwater

Storage:           Storedesiccatedassuppliedat-20°Cforupto1year.Storesolutionsat-20°Cforupto3months.


References

1.POSeglenandPBGordonetal.Proc.Natl.Acad.Sci.USA198279:1889
2.EFBlommartetal.Eur.J.Biochem.1997243:240
3.AJMcFarlandetal.Arch.Toxicol.201286:275
4.XZhaoetal.Curr.Mol.Med.201414:555
5.ZZhangetal.Oncol.Lett.201510:2941
6.HHaoetal.AnticancerDrugs201627:192 


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