Inhibitstheubiquitinligaseanaphase-promotingcomplex/cyclosome(APC/C)byinhibitingbindingandactivationbytheAPCactivatorsCdc20andCdh1.TAMEinhibitscyclinproteolysisinXenopusextracts(IC50=12µM)andinhibitsCdc20associationwithAPCat200µM.ItstABIlizescyclinB1byprematurelyterminatingubiquitination.Substratefortrypsin,thrombin,plasmin,andotherproteases.
Info
CASNo. | 1784-03-8 |
Purity | >98%(TLC);NMR(Conforms) |
MolecularWeight | 378.9Da |
PhysicalState | WhitePowder |
Quantity | 100mg |
Solubility | MaybedissolvedinDMSO(35mg/mL);orwater(35mg/mL) |
Storage | Storedesiccatedassuppliedatambienttemperatureforupto1year.Storesolutionsat-20°Cforupto3months. |
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