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Neuromics/Endoglin/CD105/GT15247/100 ug

Type:GoatIgG

 

Applications:FC;ICC;IHC;WB

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:AffinityPurified-lyophilized

 

Immunogen:MousemyelomacelllineNS0-derivedrecombinanthumanEndoglin.Glu26-Gly256AccessionNumberQ5T9B9

 

Picture

Endoglin(ENG),alsoknownasCD105,isatypeIintegraltransmembraneglycoproteinandisanaccessoryreceptorforTGF-betasuperfamilyligands.Endoglinishighlyexpressedonvascularendothelialcells,chondrocytes,andsyncytiotrophoblastsoftermplacenta.Itisalsofoundonactivatedmonocytes,mesenchymalstemcellsandleukemiccellsoflymphoidandmyeloidlineages.

Image:Endoglin/CD105wasdetectedinimmersionfixedU937humanhistiocyticlymphomacelllineusingGoatAnti-HumanEndoglin/CD105BiotinylatedAntigenAffinity-purifiedPolyclonalAntibody(Catalog#GT15247)at10 µg/mLfor3hoursatroomtemperature.Cellswerestainedusingthe 557‑conjugatedStreptavidinandcounterstainedwithDAPI(blue)

TheroleofendoglinincancercanbecontrADIctingattimessinceitisneededforneoangiogenesisintumors,whichisneededfortumorgrowthandsurvival,yetthereductioninexpressionofendoglinhasinmanycancerscorrelatedwithanegativeoutcomeofthatcancer.

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