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Neuromics/gp130/CD130/MO15024/100 ug

Type:RatIgG

 

Applications:IHC;WB;FC

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:M

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:ProteinGPurified-liquid

 

Immunogen:hybridomaresultingfromthefusionofamousemyelomawithBcellsobtainedfromaratimmunizedwithpurified,NS0-derived,recombinantmousegp130(rmgp130)extracellulardomain.

 

Gp130,thecommonsignaltransducingreceptorcomponentsharedbythefunctionalreceptorcomplexesoftheIL-6familyofcytokines,belongstotheclassIcytokinereceptorfamily.BindingofIL-6(IL-11)toeitherthemembrane-anchoredorsolubleIL-6R(IL-11R)initiatestheassociationofIL-6R(IL-11R)withgp130,whichthenundergoeshomo-dimerizationandsignaltransduction.WithotherIL-6familycytokines,suchasLIFandOSM,signaltransductionistriggeredbythehetero-dimerizationofgp130andLIFRorOSMR.

Pleasenote:thisantibodyhasbeenreferencedforuseinIHCformouseDRGs(dilution1:50).see:J.Neurosci.,Oct2009;29:13473-13483;doi:10.1523/JNEUROSCI.1822-09.2009.

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