CD130,alsoknownasgp130,isatypeItransmembranesignalingmoleculeof130-140kDathatisfoundoncellsurfacesusuallyassociatedwiththespecificreceptorchainsforthefollowingcytokines:IL-6,IL-11,leukemiainhibitoryfactor(LIF),OncostatinM,ciliaryneurotrophicfactor(CNTF)andcardiotrophin-1(CT-1)(1).TheoverlapofBIOLOGicalactivityofthesecytokinesisproofofthecommonrolethatgp130/CD130playsinthesignalingcascadeforthesemolecules.Theextracellularstructureofgp130/CD130iscomposedofsixfibronectintypeIIImodules.Asolubleformofgp130/CD130existsinserumandcanactasanantagoNISTformoleculesthatinteractwithgp130/CD130.CD130hasnointrinsickinaseactivity,however,itdoesappeartopossesssomeimportantbiologicalpropertiesthatrequireitspresenceduringtheearlystagesontogeny.Micethathaveamutatedgp130genesurviveonlyafewweekslargelyduetomyocardialmalformations(2).TheCD130moleculeformshomodimersinthepresenceofIL-6andIL-11receptors(3,4).Incontrast,CD130formsheterodimerswhenpresentwithLIFR,OSMR,CNTFRandCT-1R(5).AlthoughCD130doesnotappeartodirectlybindthesecytokines(OSMbeingtheonlyexception),itspresenceinconjunctionwiththecytokinespecificreceptorchainimpartshighaffinitybindingcharacteristicstothereceptors. MostcellsexpressCD130,however,theligandspecificreceptorsassociatedwithCD130displayamuchmorerestrictedcellularexpressionpatternultimatelydeterminingthecytokine-specificresponse.
References
antibodies gp130/CD130-Goat gp130/CD130-MouseMonoclonal IL-6(Mouse) IL-6(Rat) LIF,human LIF,mouse CDandCellSurfaceMarkerAntibodies IL,CCR,CXC,MIPandSTATAntibodies ImmuneResponseResearchAntibodies PainandInflammationResearchAntibodies proteins: IL-6_human IL-6-mouse IL-6,Human,histagged LeukemiaInhibitoryFactor(LIF),glycosylated,human LeukemiaInhibitoryFactor(LIF),mouse LeukemiaInhibitoryFactor(LIF),rat CDAntigenProteins ILs/CXCLs-RelatedCytokine&ChemokineProteins ImmuneResponseResearchProteins PrimaryNeuronsandAstrocytes-Primaryhuman,ratandmouseneuronsandastrocytes StemCellResearchReagents
SouthernBiotech/Goat Anti-Human Lambda-Alexa Fluor® 555/2070-32/1.0 mg
vectorlabs/Biotinylated Aleuria Aurantia Lectin (AAL)/B-1395/1 mg
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Mouse IgG)/PK-6102/1 kit
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Universal)/PK-6200/1 kit
vectorlabs/Unconjugated Musa Paradisiaca (Banana) Lectin (BanLec)/L-1410/5 mg
GiottoBiotech/Calmodulin N60D/5 mg/G02CLM60cn