c-Kitistransmembranetyrosinekinaseencodedbythec-Kitprotooncogene.c-KitactstoregulateavarietyofBIOLOGical processesincludingcellproliferation,apoptosis,chemotaxisandadhesion.
Itplaysacriticalroleinactivationandgrowthinanumberofcelltypessuchashematopoieticstemcells,mastcells,melanocytesandgermcells.
Mutationsinc-Kithavebeenfoundtobeimportantfortumorgrowthandprogressioninavarietyofcancersincludingmastcelldiseases,gastrointestinalstromaltumor,acutemyeloidleukemia,Ewingsarcomaandlungcancer.Phosphorylationattyrosine721ofc-KitallowsbindingandactivationofPI3kinase.
Image:c-KITstainingofratskin(epidermis).c-KITdetectionwasdoneusinganti-rabbitCy3conjugatedantibodies(redcolor).DAPIwasusedtocounterstaincellnuclei(bluecolor).Workingdilution:1:100-1:300.
c-Kit:CustomerPublications
SouthernBiotech/Goat Anti-Human Lambda-Alexa Fluor® 555/2070-32/1.0 mg
vectorlabs/Biotinylated Aleuria Aurantia Lectin (AAL)/B-1395/1 mg
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Mouse IgG)/PK-6102/1 kit
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Universal)/PK-6200/1 kit
vectorlabs/Unconjugated Musa Paradisiaca (Banana) Lectin (BanLec)/L-1410/5 mg
GiottoBiotech/Calmodulin N60D/5 mg/G02CLM60cn