Deprecated: Creation of dynamic property cls_session::$session_data_table is deprecated in /www/sites/www.188bio.com/index/systems/cls_session.php on line 49
Neuromics/Prion Protein/CD230/CH23027/200 ul188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
您好,欢迎您进入188进口试剂采购网网站! 服务热线:4000-520-616
蚂蚁淘商城 | 现货促销 | 科研狗 | 生物在线
产品资料

Neuromics/Prion Protein/CD230/CH23027/200 ul

Type:ChickenIgY

 

Applications:ICC

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H;M;R

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:AffinityPurified-liquid

 

Immunogen:RecombinantfragmentoftheHumanPrion

 

Picture

PrionproteinistheproteinresponsIBLeforhumanCreutzfeldt-JakobDisease(CJD),andsomaticmutationsofthepriongeneareresponsibleforGerstmann-Straussler-ScheinkerdiseaseandFatalFamilialInsomnia.ThebovinehomologoftheprionproteinisresponsibleforbovineSpongioformEncephalopathy(BSE),alsoknownas“MadCowDisease.”Inallcases,theprionproteinhastwofoldingstates,withonestatebeingthe“normal”non-pathologicalform,andtheotherstateinducingaspongioformencephalopathy.

Normalprionproteinsproducednaturallyinthebraininteractwiththeamyloid-βpeptidesthatarehallmarksofAlzheimer"sdisease.Blockingthisinteractioninpreparationsmadefrommousebrainshaltedsomeneurologicaldefectscausedbytheaccumulationofamyloid-βpeptide.Itwaspreviouslythoughtthatonlyinfectiousprionproteins,ratherthantheirnormal,non-infectiouscounterparts,playedaroleinbraindegeneration(Nature,doi:10.1038/news.2009.121).

Image:PrionProteinstainingofculturedfibroblastscellstransientlytransfectedwithaplasmidcontainingtheprionproteinCDNA.

新闻动态
行业前沿
技术文章
最新产品