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Hello Bio/Compound 21 (DREADD agonist 21) hydrochloride (water soluble)/HB6124/25mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Hello Bio/Compound 21 (DREADD agonist 21) hydrochloride (water soluble)/HB6124/25mg

Productoverview

  • Name
    Compound21(DREADDagoNIST21)hydrochloride(watersoluble)
  • Shortdescription
    HighlypotenthM3DqDREADDagonist.Watersoluble.
  • BIOLOGicaldescription

    Compound21(DREADDagonist21)hydrochlorideisawatersolubleanalogofclozapineN-oxide(CNO).Freebasealsoavailable.


    Compound21(DREADDagonist21)isahighlypotentagonistattheexcitatoryhM3DqDREADD(EC50=1.7nM)whichshowshighselectivityforactivatinghM3DqcomparedtothenativehM3muscarinicreceptorandotherGPCRs.


    Compound21hasminimaloff-targetactivity.ThereareindicationsthatCompound21cannotbemetabolizedvianormalroutestoclozapine(oranyrelatedcompound)and thatCompound21hasequivalentpotencyinvivowhencomparedwith clozapineN-oxide.

    UnpublisheddataindicatesthatCompound21(DREADDagonist21)activatestheinhibitoryhM4DDREADD.

    Unpublisheddataalsosuggestsusingadoseof3mg/kginratmodels.


    Compound21therefore representsanalternativetoCNO.

  • Purity
    >98%
  • Ourproductsinaction
    SubmitYourCitationNow

    • Images

    • Compound 21 HCl vial
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    Properties

    • Chemicalname
      11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepinedihydrochloride
    • MolecularWeight
      352.29
    • Chemicalstructure
      Compound 21 hydrochloride
    • MolecularFormula
      C17H18N4.2HCl
    • SMILES
      C1CN(CCN1)C2=NC3=CC=CC=C3NC4=CC=CC=C42.Cl.Cl
    • Source
      Synthetic
    • Appearance
      Yellowsolid

    StoringandUsingYourProduct

    • Storageinstructions
      RT(desiccate)
    • Solubilityoverview
      Solubleinwater(100mM)
    • Handling
      Hydroscopicsolid,contactwithairmaycausematerialtobecomesticky.Productperformanceshouldnotbeaffectedbutwerecommendstoringthematerialinasealedjar.
    • Important
      ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse

    ReferencesforCompound21(DREADDagonist21)hydrochloride(watersoluble)

    • Thefirststructure-activityrelationshipstudiesfordesignerreceptorsexclusivelyactivatedbydesignerdrugs.

      Chenetal(2015)ACSChemNeurosci6(3):476-84
      PubMedID:25587888

    • OptogeneticapproachesfordissectingneuromodulationandGPCRsignalinginneuralcircuits.

      SpanglerandBruchas(2017)CurrOpinPharmacol32(4):56-70.
      PubMedID:27875804

    • ClozapineN-OxideAdministrationProducesBehavioralEffectsinLong-EvansRats:ImplicationsforDesigningDREADDExperiments.

      MacLarenetal(2016)eNeuro3(5):0219-16
      PubMedID:27822508

    • Newnon-CNOactuatorsforDREADDs

      RothBl(2015)Blog:N/A

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