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Cellagentech/Leukadherin1 | Integrin CD11b/CD18 agonist/C53852s/2 mg (10 mM solution in DMSO)188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Cellagentech/Leukadherin1 | Integrin CD11b/CD18 agonist/C53852s/2 mg (10 mM solution in DMSO)
ProductDescription

Leukadherin-1(LA1),anovelsmallmoleculeagonistofintegrinCD11b/CD18,canincreasetheextentofCD11b/CD18-dependentcelladhesionoftransfectedcellsandofprimaryhumanandmouseneutrophils(EC50=4µMinvitro),whichresultedindecreasedchemotaxisandtransendothelialmigration.LA1canalsodecreaseleukocyterecruitmentandreducedarterialnarrowingafterinjuryinrats.Moreover,comparedtoaknownintegrinantagonist,LA1preservedkidneyfunctionbetterinamousemodelofexperimentalnephritis.Itinhibitedleukocyterecruitmentbyincreasingleukocyteadhesiontotheinflamedendothelium,whichwasreversedwithablockingantibody.

Technicalinformation:

ChemicalFormula: C22H15NO4S2
CAS#: 344897-95-6
MolecularWeight: 421.49
Purity: >98%
Appearance: Whitesolid
ChemicalName: (Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoicacid
Solubility: Upto50mMinDMSO

ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storage:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.

Reference:

1.DonyMaiguel,etal.SmallMolecule–MediatedActivationoftheIntegrinCD11b/CD18ReducesInflammatoryDisease.Sci.Signal.,Vol.4,Issue189,p.ra57
2.FaridiMHetal.IdentificationofnovelagonistsoftheintegrinCD11b/CD18.BioorgMedChemLett.2009;19(24):6902-6.


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