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Cellagentech/Ambrisentan | Endothelin receptor type A/ETa antagonist/C26275/5 mg (powder)188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Cellagentech/Ambrisentan | Endothelin receptor type A/ETa antagonist/C26275/5 mg (powder)
ProductDescription

Ambrisentanisapropanoicacid–based,orally-available,endothelinreceptortypeA-receptorantagoNISTfortheonce-dailytreatmentofpulmonaryarterialhypertension(PAH).Ithas>4000-foldselectivityforthetypeAreceptorovertypeBreceptor.StudiesindicatethatAmbrisentanhasalowpotentialfordruginteractionsandattherapeuticconcentrationsdoesnotinhibitUDP-glucuronosyltransferasesorCYPs,orinduceMDRprotein2orP-gp.(1)

Incontrastwithothersimilartherapies,Ambrisentanhasbeenshowntohavealowerpotentialforincreaseofserum-levelconcentrationsofaminotransferases.(2)

Technicalinformation:

ChemicalFormula: C22H22N2O4
CAS#: 177036-94-1
MolecularWeight: 378.42
Purity: >98%
Appearance: white
ChemicalName: (S)-2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoicacid
Solubility: Upto100mMinDMSO
Synonyms: LU-208075,BSF-208075

ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.

Reference:

1.Frampton,JE.,Ambrisentan.Am.J.Cardiovasc.Drugs2011,11(4),215-226.PubmedID:21623643
2.Galieetal.,ResultsoftheAmbrisentaninPulmonaryArterialHypertension,Randomized,Double-Blind,Placebo-Controlled,Multicenter,Efficacy(ARIES)Study1and2.Circulation,2008,117,3010-3019.PubmedID:18506008


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