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Cellagentech/GW501516 | PPARδ agonist/C49502s/2 mg (10 mM solution in DMSO)188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Cellagentech/GW501516 | PPARδ agonist/C49502s/2 mg (10 mM solution in DMSO)
ProductDescription

GW501516isaselectivePPARdagonistwithaKiaffinityof1.1nMinahumanbindingassay.Inacell-basedtransfectionassay,GW501516inducesexpressionofGAL4-responsivereportergeneatanEC50of1.2nM.Atdosesupto1uM,GW501516doesnotpromoteadipocytedifferentiation,bindtoRXRa,orhaveactivitytowardothernuclearornon-nuclearreceptors.(1)GW501516incrasesexpressionofthereversecholesteroltransporterATP-bindingcassetteA1andinducesapolipoproteinA1-specificcholesterolefflux.(1)

GW501516isalsoreportedtobeaPPARbagonistwithanti-inflammatoryactivityanddecreasesIFN-g-inducedupregulationofTNF-aandiNOS.Concurrently,GW501516increaseIL-6mRNAexpression.(2)

Technicalinformation:

ChemicalFormula: C21H18F3NO3S2
CAS#: 317318-70-0
MolecularWeight: 453.5
Purity: >98%
Appearance: white
ChemicalName: 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy)aceticacid
Solubility: Upto22mMinDMSO
Synonyms: GW501516,GW-501,516,GW1516,GSK-516,Endurobol

ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.

Reference:

1.Oliveretal.,Aselectiveperoxisomeproliferator-activatedreceptordagonistpromotesreversecholesteroltransport.Proc.Natl.Acad.Sci.2001,98(9),5306-5311.PubmedID:11309497
2.Defauxetal.,EffectsofthePPAR-bagonistGW501516inaninvitromodelofbraininflammationandantibody-induceddemyelination.J.Neuroinflammation,2009,6,15-27.PubmedID:19422681


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