Adipogen/Genistein/AGCN20427M010/10 mg

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ProductDetails
Synonyms	NSC36586;BaichaninA;DifferenolA;4,5,7-Trihydroxyisoflavone;5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
ProductType	Chemical
Properties
Formula	C₁₅H₁₀O₅
MW	270.2
MerckIndex	14:4391
CAS	446-72-0
RTECS	NR2392000
Source/HostChemicals	Synthetic.
PurityChemicals	≥99%
Appearance	Whitetooff-whitesolid.
Solubility	SolubleinDMSO;slightlysolubleinethanol.Insolubleinwater.
InChiKey	TZBJGXHYKVUXJN-UHFFFAOYSA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	-20°C
HandlingAdvice	Keepcoolanddry. Protectfromlight.
Use/Stability	Stableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

Cell-permeable,reversible,substratecompetitivetyrosinekinaseinhibitor(includingEGFRphosphorylation),implicatedinalmostallcellgrowthandproliferationsignalcascades[1].
InhibitorofmammalianDNAtopoisomeraseII[2].
Anticanceragent,inducingcellcyclearrestandapoptosis[3].
Antiangiogenicagent,down-regulatesthetranscriptionofgenesinvolvedincontrollingangiogenesis[12].
Bindsestrogenreceptorβ.CanincreasetherateofgrowthofsomeERexpressingbreastcancers[4,10].
Potentα-glucosidaseinhibitor[5].
Anthelmintic[6].
Anti-diabetic.Activatesnuclearreceptors,oestrogenreceptorsandperoxisomeproliferator-activatedreceptors(allPPARisoforms)anditinhibitsvariousenzymeactivities[7,8,14].
InhibitorofGLUT4-mediatedglucoseuptakein3T3-L1adipocytes[9].
Stimulatorofautophagyvacuolization[12].
Antioxidant[13].
TRAILsensitizer[15].
ActsasanagonistattheGPR30receptor[16].
MALT1inhibitor[17]
DNAmethyltransferaseinhibitor[18].
GenisteinexhibitssynergisticantibacterialeffectsonMRSA[19].

ProductReferences

Genistein,aspecificinhibitoroftyrosine-specificproteinkinases:T.Akiyama,etal.;J.Biol.Chem.262,5592(1987)
InhibitoryeffectsofthetyrosinekinaseinhibitorgenisteinonmammalianDNAtopoisomeraseII:J.Markovits,etal.;CancerRes.49,5111(1989)
Genisteininhibitionofthegrowthofhumanbreastcancercells:independencefromestrogenreceptorsandthemulti-drugresistancegene:G.Peterson&S.Barnes;BBRC179,661(1991)
Interactionofestrogenicchemicalsandphytoestrogenswithestrogenreceptorbeta:G.G.Kuiper,etal.;Endocrinology139,4252(1998)
Genistein,asoyisoflavone,isapotentalpha-glucosidaseinhibitor:DS.Lee&SH.Lee;FEBSLett.501,84(2001)
AnthelminticefficacyofFlemingiavestita:genistein-inducedeffectontheactivityofnitricoxidesynthaseandnitricoxideinthetrematodeparasite,Fasciolopsisbuski:P.K.Kar,etal.;Parasitol.Int.51,249(2002)
SoyisoflavonesexertantidiabeticandhypolipidemiceffectsthroughthePPARpathwaysinobeseZuckerratsandmurineRAW264.7cells:O.Mezei,etal.;J.Nutr.133,1238(2003)
Peroxisomeproliferator-activatedreceptorgamma(PPARgamma)asamoleculartargetforthesoyphytoestrogengenistein:Z.C.Dang,etal.;J.Biol.Chem.278,962(2003)
GenisteindirectlyinhibitsGLUT4-mediatedglucoseuptakein3T3-L1adipocytes:M.Bazuine,etal.;BBRC326,511(2005)
Genisteinstimulatesgrowthofhumanbreastcancercellsinanovel,postmenopausalanimalmodel,withlowplasmaestradiolconcentrationsY.H.Ju,etal.;Carcinogenesis27,1292(2006)
Phytochemicalgenisteinintheregulationofvascularfunction:newinsights:H.Si&D.Liu;Curr.Med.Chem.14,2581(2007)
Diet,autophagy,andcancer:areview:K.Singletary&J.Milner;CancerEpidemiol.BioMarkersPrev.17,1596(2008)(Review)
Comparisonofflavonoidsandisoflavonoidsasantioxidants:RM.Han,etal.;J.Agric.FoodChem.57,3780(2009)
Dose-dependenteffectsofsoyphyto-oestrogengenisteinonadipocytes:mechanismsofaction:Z.C.Dang;Obes.Rev.10,342(2009)(Review)
NovelHTSstrategyidentifiesTRAIL-sensitizingcompoundsactingspecificallythroughthecaspase-8apoptoticaxis:D.Finlay,etal.;PLoSOne5,e13375(2010)
GenisteinregulatestheIL-1betainducedactivationofMAPKsinhumanperiodontalligamentcellsthroughGprotein-coupledreceptor30:L.J.Luo,etal.;Arch.Biochem.Biophys.522,9(2012)
MALT1smallmoleculeinhibitorsspecificallysuppressABC-DLBCLinvitroandinvivo:L.Fontan,etal.;CancerCell22,812(2012)
DNAmethyltransferase-1inhibitorsasepigenetictherapyforcancer:V.Singh,etal.;Curr.CancerDrugTargets13,379(2013)
FlavonoidsfromSophoramoorcroftianaandtheirsynergisticantibacterialeffectsonMRSA:SY.Wang,etal.;Phytother.Res.28,1071(2014)

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Adipogen/Genistein/AGCN20427M010/10 mg