Adipogen/IAXO102 (CD14/TLR4 Antagonist) (synthetic)/IAX600002M005/5 mg

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ProductDetails
Synonyms	Methyl6-deoxy-6-amino-2,3-di-O-tetradecyl-α-D-glucopyranoside
ProductType	Chemical
Properties
Formula	C₃₅H₇₁NO₅
MW	585.94g/mol
CAS	1115270-63-7
Source/HostChemicals	Synthetic.
PurityChemicals	≥98%(TLC)
Appearance	Whitesolid.
Solubility	SolubleinMethanol,DMSOandEthanol1:1(vol:vol):>10mM.
BiologicalActivity	Describedtointerferewithhuman,ratandmouseTLR4/CD14signaling,otherspeciesnottested.Optimalworkingconcentrationdependsuponthetype,purityandconcentrationandofTLR4ligand,carrierproteinsuchasLPS-bindingprotein(LBP),solubleandmembrane-boundCD14,thepresenceofTLR4co-receptors(e.g.CD36)aswellasontypeandtimeofread-out(e.g.cytokinemeasurementincellculturesupernatant)orthebiologicaloutcomeofinvivoexperimentsandthereforeneedstobedeterminedforeachapplication.Recommendedstartingconcentration:invitro:5μM,invivo(rodent):3mg/kg.Controlcompound:IAXO-201(Cat.No.:IAX-600-004).
Identity	DeterminedbyNMRandMS.
Declaration	ManufacturedbyInnaxon.
OtherProductData	Reconstitution:Fora2mMstocksolution,dissolvetotalvialcontentin853μl(1mgsize)or4,266μl(5mgsize)in(1:1)DMSO/Ethanol(vol:vol). ClickhereforOriginalManufacturerProductDatasheet:Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
InChiKey	InChI=1/C35H71NO5/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-39-33-32(37)31(30-36)41-35(38-3)34(33)40-29-27-25-23-21-19-17-15-13-11-9-7-5-2/h31-35,37H,4-30,36H2,1-3H3
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	+4°C
Use/Stability	Stableforatleast1yearafterreceiptwhenstoredat+4°C.
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MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

CD14/TLR4antagonist.Inhibitorofsterileinflammation.
SyntheticTLR4/CD14ligandwithTLR4modulatingactivitiesinvitro,andconferringprotectionagainstTLR4/CD14-mediatedtissuedamageandinflammationinvivo.UsefultoexploreCD14-dependentandTLR4-independentpathwaysandTLR4activationbyendogenousligands(e.g.hyaluronicacidoligosaccharides,oxLDL,HMGB1)insterileinflammation.Showntoinhibitneuropathicpain,secondarynecrosisofacutedrug-inducedliverfailureandvascularinflammation,andabdominalaorticaneurysmbyblockingnon-hematopoieticTLR4signaling.Usefultool,whereinhibitionofsterile(auto-)inflammationisdesired,withoutcompromisingTLR4’skeyroleinthedefenseofpathogens.

ProductReferences

Inhibitionoflipidastimulatedactivationofhumandendriticcellsandmacrophagesbyaminoandhydroxylaminomonosaccharides:F.Peri,etal.;Angew.Chem.46,3308(2007)
TLR4receptorasnewtargettotreatneuropathicpain:efficacyofanewreceptorantagonistinamodelofperipheralnerveinjuryinmice:I.Bettoni,etal.;Glia56,1312(2008)
Glycolipidsandbenzylammoniumlipidsasnovelantisepsisagents:synthesisandbiologicalcharacterization:M.Piazza,etal.;J.Med.Chem.52,1209(2009)
EvidenceofaspecificinteractionbetweennewsyntheticantisepsisagentsandCD14:M.Piazza,etal.;Biochemistry48,12337(2009)
ExploringtheLPS/TLR4signalpathwaywithsmallmolecules:F.Peri,etal.;Biochem.Soc.Trans.38,1390(2010)(Review)
TherapeutictargetingofinnateimmunitywithToll-likereceptor4(TLR4)antagonists:F.Peri&M.Piazza;Biotechnol.Adv.30,251(2012)(Review)
SyntheticmoleculesandfunctionalizednanoparticlestargetingtheLPS-TLR4signaling:Anewgenerationofimmunotherapeutics:F.Peri,etal.;PureAppl.Chem.84,97(2012)(Review)
Tolllikereceptor4antagonistpreventsacetaminopheninducedacuteliverfailureinmice:anoveltherapeuticstrategy:N.Shah,etal.;Gut61,A28(2012)
Multivalentglycoconjugatesasanti-pathogenicagents.A.Bernardi,etal.;Chem.Soc.Rev.42,4709(2013)(Review)
Toll-likereceptor4(TLR4)modulationbysyntheticandnaturalcompounds:anupdate:F.Peri&V.Calabrese;Med.Chem.57,3612(2014)(Review)
AnovelsmallmimeticmoleculeTLR4antagonist(IAXO-102)modulatesTLR4proinflammatorysignallingandinhibitsaorticaneurysmsdevelopment:C.Huggins,etal.;Atherosclerosis241,e53(2015)

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Adipogen/IAXO102 (CD14/TLR4 Antagonist) (synthetic)/IAX600002M005/5 mg