productdatasheet
E.coli.
ThisantibodyrecognizeshumanRad51,a37kDproteinthatinteractswithBRCA1.Thisinteractionisimportantfortumorsuppression.BRCA2andRad51havealsobeenshowntointeractviatheBRCrepeatslocatedwithexon11ofBRCA2.Whentheserepeatsaredeleted,theinteractionislost,andcellsbecomehypersensitivetoDNAdamagecausedbymethylmethanesulfonate(MMS).
APPLICATIONSImmunoblotting,immunoprecipitation:useat1-5ug/ml.
Positivecontrol:T24bladdercarcinomacellsandrecombinantfusionprotein.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-70oC.Avoidmultiplefreeze-thawcycles.
Shinohara,Aetal.1993.NatureGenetics4:239-243;Scully,Retal.1997.Cell88:265-275;Chen,PLetal.
1998.PNAS(USA)95:5287-5292.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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